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Associations between fluctuations in daytime sleepiness and motor and non-motor symptoms in Parkinson's disease
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- Höglund, Arja (författare)
- Karolinska institutet & Karolinska universitetssjukhuset
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- Hagell, Peter (författare)
- Högskolan Kristianstad,Forskningsmiljön PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education,Avdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap
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- Broman, Jan-Erik (författare)
- Uppsala universitet
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- Pålhagen, Sven (författare)
- Karolinska institutet & Karolinska universitetssjukhuset
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- Sorjonen, Kimmo (författare)
- Karolinska institutet
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- Fredrikson, Sten (författare)
- Karolinska institutet & karolinska universitetssjukhuset
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- Svenningsson, Per (författare)
- Karolinska institutet & Karolinska universitetssjukhuset
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- Fredrikson, S (författare)
- Karolinska Institutet
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Hagell, P (författare)
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Broman, JE (författare)
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- Höglund, A (författare)
- Karolinska Institutet
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- Svenningsson, P (författare)
- Karolinska Institutet
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- Pålhagen, S (författare)
- Karolinska Institutet
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- Sorjonen, K (författare)
- Karolinska Institutet
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- Palhagen, S (författare)
- Karolinska Institutet
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- Hoglund, A (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2021
- 2021
- Engelska.
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Ingår i: Movement Disorders Clinical Practice. - 2330-1619. ; 8:1, s. 44-50
- Relaterad länk:
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https://movementdiso...
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https://onlinelibrar...
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https://doi.org/10.1...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Abstract Background Non-motor fluctuations (NMF) are a major concern in Parkinson's disease (PD), and they have been categorised into neuropsychiatric, autonomic and sensory fluctuations. However, this categorisation does not include sleep and sleep-related features, and the association between daytime sleepiness and other motor and/or non-motor fluctuations in PD remains to be elucidated. Objective To investigate the relationship between daytime sleepiness and other non-motor and motor fluctuations in people with PD. Methods A three-day home diary recording daytime sleepiness, mood, anxiety, and motor symptoms was used along with the Karolinska Sleepiness Scale (KSS) and six days of accelerometer (Parkinson's KinetiGraph?; PKG?) registration to detect motor fluctuations among people with a DaTSCAN verified clinical PD diagnosis (32 men; mean PD duration, 8.2?years). Participants were categorised as motor fluctuators or non-fluctuators according to the UPDRS part IV and/or the presence of motor and non-motor fluctuations. Results Fifty-two people with PD participated. Daytime sleepiness correlated significantly with motor symptoms, mood and anxiety among those classified as motor fluctuators (n = 28). Motor fluctuators showed stronger correlations between the individual mean level of all diary variables (daytime sleepiness, anxiety, mood and motor symptoms) when compared to the non-fluctuators (n = 24). Stronger positive within-individual correlations were found among fluctuators in comparison to non-fluctuators. In general, PKG data did not correlate with diary data. Conclusion Episodes of daytime sleepiness, as reported by home diaries, were associated with other self-reported non-motor and motor fluctuations, but were not supported by PKG data.
Ämnesord
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskaper (hsv//swe)
Nyckelord
- Daytime sleepiness
- Parkinson's disease
- motor fluctuations and non-motor fluctuations
- home diary
- PKG
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
- Av författaren/redakt...
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Höglund, Arja
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Hagell, Peter
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Broman, Jan-Erik
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Pålhagen, Sven
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Sorjonen, Kimmo
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Fredrikson, Sten
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visa fler...
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Svenningsson, Pe ...
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Fredrikson, S
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Hagell, P
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Broman, JE
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Höglund, A
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Svenningsson, P
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Pålhagen, S
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Sorjonen, K
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Palhagen, S
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Hoglund, A
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskaper
- Artiklar i publikationen
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Movement Disorde ...
- Av lärosätet
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Högskolan Kristianstad
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Karolinska Institutet