The Prostaglandin E1 Analog Misoprostol Reduces Symptoms and Microvascular Arteriovenous Shunting in Erythromelalgia: A Double-Blind, Crossover, Placebo-Compared Study

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Fältnamn	Indikatorer	Metadata
000		05170naa a2200625 4500
001		oai:DiVA.org:kau-2218
003		SwePub
008		111016s2004 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:kau-24700
009		oai:DiVA.org:liu-22156
009		oai:DiVA.org:kau-3195
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-22182 URI
024	7	a https://doi.org/10.1111/j.0022-202X.2004.22339.x2 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-247002 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-221562 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-31952 URI
040		a (SwePub)kaud (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Mørk, Catou Department of Dermatology, Rikshospitalet University Hospital, Norway4 aut
245	1 0	a The Prostaglandin E1 Analog Misoprostol Reduces Symptoms and Microvascular Arteriovenous Shunting in Erythromelalgia :b A Double-Blind, Crossover, Placebo-Compared Study
264	1	b Nature Publishing Group,c 2004
338		a electronic2 rdacarrier
520		a Based on previous experience with parenteral prostanoids, we studied the effect of misoprostol treatment, an orally administered prostaglandin E1 analog, in patients with erythromelalgia. Treatment with placebo was followed by treatment with misoprostol (0.4–0.8 mg per d), both for 6 wk. The patients (n=21) and a study nurse who administered the trial were blinded. The endpoints were change in pain and need for cooling and global assessment of the treatment. Following central body heat provocation, global skin perfusion, capillary morphology, and change in pain were also recorded before and after each treatment period. Results were compared with data from healthy control subjects (n=11) that did not undergo treatment. Clinical safety and tolerability evaluation included physical examinations, clinical laboratory tests, and monitoring of adverse events. All clinical outcome measures were significantly better after treatment with misoprostol (p<0.01) as compared with placebo treatment and after a 3-mo follow-up without treatment. The heat-induced increase in global perfusion after misoprostol treatment was similar to the control group and significantly lower when compared with baseline (p<0.01) and placebo treatment (p<0.05), respectively. This study demonstrates that misoprostol is clinically superior to placebo in patients with erythromelalgia. The results of the perfusion studies may imply that the mechanism of action of the beneficial effect of misoprostol is reduced microvascular arteriovenous shunting in affected skin.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng
650	7	a NATURVETENSKAPx Data- och informationsvetenskapx Datorseende och robotik0 (SwePub)102072 hsv//swe
650	7	a NATURAL SCIENCESx Computer and Information Sciencesx Computer Vision and Robotics0 (SwePub)102072 hsv//eng
653		a arteriovenous shunting
653		a clinical trial
653		a microcirculation
653		a prostanoids
653		a Dermatology and venerology
653		a Dermatologi och venerologi
653		a MEDICINE
653		a Image analysis
653		a Biomedicinsk lab. Vetenskap
700	1	a Salerud, Göran,d 1954-u Linköpings universitet,Tekniska högskolan,Biomedicinsk instrumentteknik,Department of Biomedical Engineering, Linköping University4 aut0 (Swepub:liu)gorsa75
700	1	a Asker, Claes L,d 1966-u Karlstads universitet,Institutionen för kemi4 aut0 (Swepub:kau)claeaske
700	1	a Kvernebo, Knutu Department of Cardiothoracic Surgery, Ullevaal University Hospital, Norway4 aut
710	2	a Department of Dermatology, Rikshospitalet University Hospital, Norwayb Tekniska högskolan4 org
773	0	t Journal of Investigative Dermatologyd : Nature Publishing Groupg 122:3, s. 587-593q 122:3<587-593x 0022-202Xx 1523-1747
773	0	t Journal of Investigative Dermatology Volume 122, Issue 3, Page 587-593, Mar 2004d : Nature Publishing Groupg 122:3, s. 587-593q 122:3<587-593
856	4	u https://kau.diva-portal.org/smash/get/diva2:24558/FULLTEXT01.pdfx primaryx Raw objecty fulltext:preprint
856	4	u http://dx.doi.org/10.1111/j.0022-202X.2004.22339.x
856	4	u http://kau.diva-portal.org/smash/get/diva2:128368/FULLTEXT01
856	4	u http://www.nature.com/jid/journal/v122/n3/full/5602219a.html
856	4	u https://kau.diva-portal.org/smash/get/diva2:128368/FULLTEXT01.pdfx primaryx Raw objecty fulltext:postprint
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-2218
856	4 8	u https://doi.org/10.1111/j.0022-202X.2004.22339.x
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-24700
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-22156
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-3195

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Av författaren/redakt...: Mørk, Cato; Salerud, Göran, ...; Asker, Claes L, ...; Kvernebo, Knut

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