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Cytotoxic Cembranoi...
Cytotoxic Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum
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- Hegazy, Mohamed-Elamir F. (författare)
- Natl Res Ctr, Pharmaceut Res Lab, Ctr Excellence Adv Sci, Cairo 12622, Egypt.;Natl Res Ctr, Chem Med Plants Dept, Giza 12622, Egypt.
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- El-Beih, Ahmed A. (författare)
- Natl Res Ctr, Pharmaceut Res Lab, Ctr Excellence Adv Sci, Cairo 12622, Egypt.;Natl Res Ctr, Chem Nat & Microbial Prod Dept, Giza 12622, Egypt.
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- Moustafa, Alaa Y. (författare)
- Sohag Univ, Dept Zool, Fac Sci, Sohag, Egypt.
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visa fler...
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- Hamdy, Abdelhamed A. (författare)
- Natl Res Ctr, Chem Nat & Microbial Prod Dept, Giza 12622, Egypt.
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- Alhammady, Montaser A. (författare)
- Natl Inst Oceanog & Fisheries, Red Sea Branch, Hurghada, Egypt.
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- Selim, Rehab M. (författare)
- Natl Res Ctr, Chem Nat & Microbial Prod Dept, Giza 12622, Egypt.
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- Abdel-Rehim, Mohamed (författare)
- Karlstads universitet,Avdelningen för kemi och biomedicinsk vetenskap,Natl Res Ctr, Pharmaceut Res Lab, Ctr Excellence Adv Sci, Cairo 12622, Egypt.;Karlstad Univ, Dept Chem & Biomed Sci, Fac Sci & Technol, SE-65188 Karlstad, Sweden.;Astra Zeneca, R&D, Dept Clin Pharmacol, S-15185 Sodertalje, Sweden.;Astra Zeneca, R&D, DMPK, S-15185 Sodertalje, Sweden.
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- Pare, Paul W. (författare)
- Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA.
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visa färre...
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Natl Res Ctr, Pharmaceut Res Lab, Ctr Excellence Adv Sci, Cairo 12622, Egypt;Natl Res Ctr, Chem Med Plants Dept, Giza 12622, Egypt. Natl Res Ctr, Pharmaceut Res Lab, Ctr Excellence Adv Sci, Cairo 12622, Egypt.;Natl Res Ctr, Chem Nat & Microbial Prod Dept, Giza 12622, Egypt. (creator_code:org_t)
- 2011
- 2011
- Engelska.
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Ingår i: Natural Product Communications. - 1934-578X .- 1555-9475. ; 6:12, s. 1809-1812
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7 alpha,8 beta-dihydroxydecpoxysarcophine (2), 7 beta-acetoxy-8 alpha-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7 beta-Acetoxy-8 alpha-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC(50) values of 3.6, 2.3, and 6.7 mu g/mL, respectively.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- Sarcophyton glaucum
- cembrane diterpenes
- dihydroxydeepoxysarcophine
- sarcophine
- Kemi
- Chemistry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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