Sökning: onr:"swepub:oai:DiVA.org:kau-73525" >
Early pregnancy ser...
Early pregnancy serum levels of perfluoroalkyl substances and risk of preeclampsia in Swedish women.
-
- Wikström, Sverre (författare)
- Örebro University,Karlstad University,Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Örebro universitet,Institutionen för medicinska vetenskaper,Department of Health Sciences, Karlstad University, Karlstad, Sweden
-
- Lindh, Christian H. (författare)
- Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
-
- Shu, Huan, 1980- (författare)
- Stockholm University,Karlstad University,Stockholms universitet,Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Department of Health Sciences, Karlstad University, Karlstad, Sweden; Department of environmental Science and Analytical chemistry, Stockholm University, Stockholm, Sweden,Institutionen för miljövetenskap och analytisk kemi
-
visa fler...
-
- Bornehag, Carl-Gustaf, 1957- (författare)
- Karlstad University,Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn School of Medicine at Mount Sinai, NY, United States,Department of Health Sciences, Karlstad University, Karlstad, Sweden; Department of Preventive Medicine, icahn School of Medicine at Mount Sinai, New York, USA
-
visa färre...
-
(creator_code:org_t)
- 2019-06-24
- 2019
- Engelska.
-
Ingår i: Scientific Reports. - : Springer. - 2045-2322. ; 9:1, s. 1-7
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://kau.diva-por... (primary) (Raw object)
-
https://www.nature.c...
-
http://dx.doi.org/10... (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
visa färre...
Abstract
Ämnesord
Stäng
- Preeclampsia is a major cause of maternal and fetal morbidity. Emerging research shows an association with environmental exposures. The present aim was to investigate associations between early pregnancy serum levels of perfluoroalkyl substances (PFAS) and preeclampsia. Within the Swedish SELMA study, eight PFAS were measured at median 10 gestational weeks and cases of preeclampsia were postnatally identified from registers. Associations between individual PFAS and preeclampsia were assessed, adjusting for parity, age, weight and smoking. Out of 1,773 women in the study group, 64 (3.6%), developed preeclampsia. A doubling of PFOS and PFNA exposure, corresponding to an inter-quartile increase, was associated with an increased risk for preeclampsia of about 38-53% respectively. Serum PFOS within the highest quartile was associated with an odds ratio of 2.68 (CI 95%: 1.17-6.12), equal to the increased risk associated with nulliparity, when compared to exposure in the first quartile. The same associations were identified, although with higher risk estimates, in analyses restricted to nulliparous women. For other PFAS, there were no associations. In conclusion and consistent with limited previous research only on PFOS, increasing serum levels of PFOS and PFNA during early pregnancy were associated with a clinically relevant risk of preeclampsia, adjusting for established confounders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Public Health Science
- Folkhälsovetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas