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Infiltrating immune...
Infiltrating immune cells in prostate cancer tissue after androgen deprivation and radiotherapy
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- Erlandsson, Ann, 1968- (författare)
- Örebro universitet, Sverige,Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Department of Environmental and Life Sciences/Biology, Karlstad University, Karlstad, Sweden
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- Lundholm, Marie, 1974- (författare)
- Umeå universitet,Patologi,Umeå universitet, Sverige
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- Watz, Johan, 1977- (författare)
- Karlstads universitet,Institutionen för miljö- och livsvetenskaper (from 2013),Department of Environmental and Life Sciences/Biology, Karlstad University, Karlstad, Sweden
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- Bergh, Anders (författare)
- Umeå universitet,Patologi,Umeå universitet, Sverige
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- Petrova, Elitsa (författare)
- Department of Clinical Pathology and Cytology, Central Hospital Karlstad, Karlstad, Sweden
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- Alamdari, Farhood (författare)
- Department of Urology, Västmanlands Hospital, Västerås, Sweden
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- Helleday, Thomas (författare)
- Karolinska Institutet
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- Davidsson, Sabina, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro universitet, Sverige
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- Andren, Ove (författare)
- Örebro universitet, Sverige,Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Tarish, Firas (författare)
- Karolinska Institutet, Sverige,Department of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden
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(creator_code:org_t)
- 2023-03-06
- 2023
- Engelska.
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Ingår i: International journal of immunopathology and pharmacology. - : Sage Publications. - 0394-6320 .- 2058-7384. ; 37
- Relaterad länk:
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https://doi.org/10.1...
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https://kau.diva-por... (primary) (Raw object)
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives: Androgen deprivation therapy (ADT) has long been a cornerstone in treatment of advanced prostate cancer (PCa), and is known to improve the results of radiotherapy (RT) for high-risk disease. The purpose of our study was to use a multiplexed immunohistochemical (mIHC) approach to investigate the infiltration of immune cells in PCa tissue after eight weeks of ADT and/or RT with 10 Gy.Methods: From a cohort of 48 patients divided into two treatment arms, we obtained biopsies before and after treatment and used a mIHC method with multispectral imaging to analyze the infiltration of immune cells in tumor stroma and tumor epithelium, focusing on areas with high infiltration.Results: Tumor stroma showed a significantly higher infiltration of immune cells compared to tumor epithelium. The most prominent immune cells were CD20(+) B-lymphocytes, followed by CD68(+) macrophages, CD8(+) cytotoxic T-cells, FOXP3(+) regulatory T-cells (Tregs), and T-bet(+) Th1-cells. Neoadjuvant ADT followed by RT significantly increased the infiltration of all five immune cells. Numbers of Th1-cells and Tregs significantly increased after single treatment with ADT or RT. In addition, ADT alone increased the number of cytotoxic T-cells and RT increased the number of B-cells.Conclusions: Neoadjuvant ADT in combination with RT results in a higher inflammatory response compared to RT or ADT alone. The mIHC method may be a useful tool for investigating infiltrating immune cells in PCa biopsies to understand how immunotherapeutic approaches can be combined with current PCa therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Prostate cancer
- androgen deprivation therapy
- radiotherapy
- immune cells
- multiplex IHC
- Biology
- Biologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Erlandsson, Ann, ...
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Lundholm, Marie, ...
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Watz, Johan, 197 ...
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Bergh, Anders
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Petrova, Elitsa
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Alamdari, Farhoo ...
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visa fler...
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Helleday, Thomas
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Davidsson, Sabin ...
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Andren, Ove
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Tarish, Firas
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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International jo ...
- Av lärosätet
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Karlstads universitet
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Örebro universitet
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Umeå universitet
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Karolinska Institutet