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First Aldol Cross-L...
First Aldol Cross-Linked Hyaluronic Acid Hydrogel : Fast and Hydrolytically Stable Hydrogel with Tissue Adhesive Properties
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- Bermejo-Velasco, Daniel, 1985- (författare)
- Uppsala universitet,Polymerkemi,Uppsala University, Sweden
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- Kadekar, Sandeep (författare)
- Uppsala universitet,Polymerkemi,Uppsala University, Sweden
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- Tavares da Costa, Marcus Vinicius, 1989- (författare)
- Uppsala universitet,Tillämpad mekanik,Uppsala University, Sweden
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- Varghese, Oommen P., 1977- (författare)
- Uppsala universitet,Polymerkemi,Uppsala University, Sweden
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- Gamstedt, E. Kristofer (författare)
- Uppsala universitet,Tillämpad mekanik,Uppsala University, Sweden
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- Hilborn, Jöns, 1956- (författare)
- Uppsala universitet,Polymerkemi,Uppsala University, Sweden
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- Varghese, Oommen P., 1977- (författare)
- Uppsala University, Sweden
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- Oommen, Oommen P. (författare)
- Tampere University, Finland
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(creator_code:org_t)
- 2019-09-25
- 2019
- Engelska.
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 11:41, s. 38232-38239
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Currently, there are limited approaches to tailor 3D scaffolds cross-linked with a stable covalent C-C bond that does not require any catalysts or initiators. We present here the first hydrogels employing aldol condensation chemistry that exhibit exceptional physicochemical properties. We investigated the aldol-cross-linking chemistry using two types of aldehyde-modified hyaluronic acid (HA) derivatives, namely, an enolizable HA-aldehyde (HA-EaI) and a non-enolizable HA-aldehyde (HA-NaI). Hydrogels formed using HA-EaI demonstrate inferior cross linking efficiency (due to intramolecular loop formation), when compared with hydrogels formed by mixing HA-EaI and HA-NaI leading to a cross-aldol product. The change in mechanical properties as a result of cross-linking at different pH values is determined using rheological measurements and is interpreted in terms of molecular weight between cross-links (Me). The novel HA cross-aldol hydrogel demonstrate excellent hydrolytic stability and favorable mechanical properties but allow hyaluronidase-mediated enzymatic degradation. Interestingly, residual aldehyde functionality within the aldol product rendered the tissue adhesive properties by bonding two bone tissues. The aldehyde functionality also facilitated facile post-synthetic modifications with nucleophilic reagents. Finally, we demonstrate that the novel hydrogel is biocompatible with encapsulated stem cells that show a linear rate of expansion in our 3-6 days of study.
Ämnesord
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
Nyckelord
- hyaluronic acid
- hydrogel
- aldol chemistry
- tissue adhesive
- biomaterial
- Construction Engineering
- Byggteknik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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