Sökning: onr:"swepub:oai:DiVA.org:kth-12100" >
The importance of a...
The importance of an endotoxin-free environment during the production of nanoparticles used in medical applications
-
- Vallhov, Helen (författare)
- Karolinska Institutet
-
- Qin, Jian (författare)
- KTH,Funktionella material, FNM
-
Johansson, Sara M. (författare)
-
visa fler...
-
Ahlborg, Niklas (författare)
-
- Muhammed, Mamoun A. (författare)
- KTH,Funktionella material, FNM
-
- Scheynius, Annika (författare)
- Karolinska Institutet
-
- Gabrielsson, Susanne (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2006-07-22
- 2006
- Engelska.
-
Ingår i: Nano letters (Print). - : American Chemical Society (ACS). - 1530-6984 .- 1530-6992. ; 6:8, s. 1682-1686
- Relaterad länk:
-
http://pubs.acs.org/...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- We investigated the effect of spherical gold nanoparticles on immature dendritic cells (DCs). Conventionally produced nanoparticles had a maturating effect on the DCs-a result of lipopolysaccharide (LPS) contamination. By modification of the production process, low-LPS particles were obtained, which had practically no effect on phenotypic maturation or cytokine production of the DCs. Our findings emphasize the importance of high purity in the production of nanoparticles, since possible contaminants may interfere with the assessment of biological/medical effects. They also highlight that nanoparticles can function as carriers of immune modulating contaminants.
Ämnesord
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
Nyckelord
- human dendritic cells
- gold
- immunity
- lipopolysaccharide
- contamination
- maturation
- particles
- receptor
- innate
- metal
- Materials chemistry
- Materialkemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas