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Biodegradable polym...
Biodegradable polymeric vesicles containing magnetic nanoparticles, quantum dots and anticancer drugs for drug delivery and imaging
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- Ye, Fei (författare)
- Karolinska Institutet
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- Barrefelt, Asa (författare)
- Karolinska Institutet
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Asem, Heba (författare)
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- Abedi-Valugerdi, Manuchehr (författare)
- Karolinska Institutet
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- El-Serafi, Ibrahim (författare)
- Karolinska Institutet
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- Saghafian, Maryam (författare)
- Karolinska Institutet
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Abu-Salah, Khalid (författare)
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Alrokayan, Salman (författare)
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- Muhammed, Mamoun (författare)
- Karolinska Institutet,KTH,Funktionella material, FNM
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Hassan, Moustapha (författare)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- Engelska.
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Ingår i: Biomaterials. - : Elsevier BV. - 0142-9612 .- 1878-5905. ; 35:12, s. 3885-3894
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- We have developed biodegradable polymeric vesicles as a nanocarrier system for multimodal bioimaging and anticancer drug delivery. The poly(lactic-co-glycolic acid) (PLGA) vesicles were fabricated by encapsulating inorganic imaging agents of superparamagnetic iron oxide nanoparticles (SPION), manganese-doped zinc sulfide (Mn:ZnS) quantum dots (QDs) and the anticancer drug busulfan into PLGA nanoparticles via an emulsion-evaporation method. T-2(*)-weighted magnetic resonance imaging (MRI) of PLGA-SPION-Mn:ZnS phantoms exhibited enhanced negative contrast with r(2)(*) relaxivity of approximately 523 s(-1) mM(-1) Fe. Murine macrophage (J774A) cellular uptake of PLGA vesicles started fluorescence imaging at 2 h and reached maximum intensity at 24 h incubation. The drug delivery ability of PLGA vesicles was demonstrated in vitro by release of busulfan. PLGA vesicle degradation was studied in vitro, showing that approximately 32% was degraded into lactic and glycolic acid over a period of 5 weeks. The biodistribution of PLGA vesicles was investigated in vivo by MRI in a rat model. Change of contrast in the liver could be visualized by MRI after 7 min and maximal signal loss detected after 4 h post-injection of PLGA vesicles. Histological studies showed that the presence of PLGA vesicles in organs was shifted from the lungs to the liver and spleen over time.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Nyckelord
- Biodegradable polymer
- Multifunctional nanoparticles
- Anticancer drug delivery
- Busulfan
- Fluorescence imaging
- Magnetic resonance imaging
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ye, Fei
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Barrefelt, Asa
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Asem, Heba
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Abedi-Valugerdi, ...
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El-Serafi, Ibrah ...
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Saghafian, Marya ...
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visa fler...
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Abu-Salah, Khali ...
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Alrokayan, Salma ...
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Muhammed, Mamoun
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Hassan, Moustaph ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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och Biomaterialveten ...
- Artiklar i publikationen
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Biomaterials
- Av lärosätet
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Kungliga Tekniska Högskolan
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Karolinska Institutet