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Functional role of ...
Functional role of entorhinal cortex in working memory processing
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- Fransén, Erik, 1962- (författare)
- KTH,Numerisk Analys och Datalogi, NADA
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- Engelska.
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Ingår i: Neural Networks. - : Elsevier BV. - 0893-6080 .- 1879-2782. ; 18:9, s. 1141-1149
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Our learning and memory system has the challenge to work in a world where items to learn are dispersed in space and time. From the information extracted by the perceptual systems, the learning system must select and combine information. Both these operations may require a temporary storage where significance and correlations could be assessed. This work builds on the common hypothesis that hippocampus and subicular, entorhinal and parahippocampal/postrhinal areas are essential for the above-mentioned functions. We bring up two examples of models: the first one is modeling of in vivo and in vitro data from entorhinal cortex layer 11 of delayed match-to-sample working memory experiments, the second one studying mechanisms in theta rhythmicity in EC. In both cases, we discuss how cationic currents might be involved and relate their kinetics and pharmacology to behavioral and cellular experimental results.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Nyckelord
- working memory
- delay match-to-sample
- theta oscillations
- biophysical modeling
- layer-ii neurons
- visual recognition memory
- hippocampal theta-rhythm
- subthreshold oscillations
- pyramidal neuron
- cation current
- nmda channels
- delayed match
- h-current
- model
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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