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Crystal structure a...
Crystal structure and physical properties of two polymorphs of ropivacaine HCl
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Bergstrom, P. O. (författare)
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- Fischer, Andreas (författare)
- KTH,Oorganisk kemi
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- Kloo, Lars A. (författare)
- KTH,Oorganisk kemi
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Sebhatu, T. (författare)
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- Engelska.
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Ingår i: Journal of Pharmaceutical Sciences. - : Elsevier BV. - 0022-3549 .- 1520-6017. ; 95:3, s. 680-688
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The crystal structure of two polymorphs of ropivacaine HCl have been determined, as well as their relative stability up to 100 degrees C. A geometric restriction for a solid-state transition between the two polymorphs has been identified. The packing density along the H-bonded chains form the basis for a model explaining the kinetic crystallization of the metastable form. The difference in stability and physicochemical properties between the two polymorphs can be attributed to the difference in crystal structure.
Nyckelord
- crystal structure
- polymorphism
- physical stability
- solution calorimetry
- solubility
- solid state
- thermodynamics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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