Sökning: onr:"swepub:oai:DiVA.org:kth-158806" > Impact of ABCB1 sin...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05860naa a2200733 4500 | |
001 | oai:DiVA.org:kth-158806 | |
003 | SwePub | |
008 | 150112s2014 | |||||||||||000 ||eng| | |
009 | oai:gup.ub.gu.se/206475 | |
009 | oai:DiVA.org:liu-112996 | |
009 | oai:prod.swepub.kib.ki.se:130134492 | |
009 | oai:DiVA.org:uu-239739 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1588062 URI |
024 | 7 | a https://doi.org/10.1111/bjh.130972 DOI |
024 | 7 | a https://gup.ub.gu.se/publication/2064752 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1129962 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1301344922 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2397392 URI |
040 | a (SwePub)kthd (SwePub)gud (SwePub)liud (SwePub)kid (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Jakobsen Falk, Ingridu Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet4 aut0 (Swepub:liu)ingja10 |
245 | 1 0 | a Impact of ABCB1 single nucleotide polymorphisms 1236C>T and 2677G>T on overall survival in FLT3 wild-type de novo AML patients with normal karyotype |
264 | c 2014-08-23 | |
264 | 1 | b Wiley,c 2014 |
338 | a print2 rdacarrier | |
500 | a QC 20150202 | |
500 | a Funding Agencies|Swedish Cancer Society; County Council of Ostergotland; AFA Insurance; Stockholm Cancer Society; Karolinska Institutet; Swedish Research Council | |
520 | a Drug resistance is a clinically relevant problem in the treatment of acute myeloid leukaemia (AML). We have previously reported a relationship between single nucleotide polymorphisms (SNPs) of ABCB1, encoding the multi-drug transporter P-glycoprotein, and overall survival (OS) in normal karyotype (NK)-AML. Here we extended this material, enabling subgroup analysis based on FLT3 and NPM1 status, to further elucidate the influence of ABCB1 SNPs. De novo NK-AML patients (n = 201) were analysed for 1199G>A, 1236C>T, 2677G>T/A and 3435C>T, and correlations to outcome were investigated. FLT3 wild-type 1236C/C patients have significantly shorter OS compared to patients carrying the variant allele; medians 20 vs. 49 months, respectively, P = 0.017. There was also an inferior outcome in FLT3 wild-type 2677G/G patients compared to patients carrying the variant allele, median OS 20 vs. 35 months, respectively, P = 0.039. This was confirmed in Cox regression analysis. Our results indicate that ABCB1 1236C>T and 2677G>T may be used as prognostic markers to distinguish relatively high risk patients in the intermediate risk FLT3 wild-type group, which may contribute to future individualizing of treatment strategies. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
653 | a acute myeloid leukaemia | |
653 | a ABCB1 | |
653 | a single nucleotide polymorphism | |
653 | a anthracyclines | |
653 | a FLT3 | |
653 | a ABCB1; FLT3; acute myeloid leukaemia; anthracyclines; single nucleotide polymorphism | |
700 | 1 | a Fyrberg, Annau Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet4 aut0 (Swepub:liu)annfy07 |
700 | 1 | a Paul, Esbjornu Karolinska Institute, Sweden4 aut |
700 | 1 | a Nahi, Harethu Karolinska Institutet4 aut |
700 | 1 | a Hermanson, Monicau Uppsala universitet,Medicinsk genetik4 aut0 (Swepub:uu)moniherm |
700 | 1 | a Rosenquist, Richard Brandellu Uppsala universitet,Hematologi och immunologi4 aut0 (Swepub:uu)richrose |
700 | 1 | a Höglund, Martinu Uppsala universitet,Hematologi4 aut0 (Swepub:uu)martinhl |
700 | 1 | a Palmqvist, Lars,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,University of Gothenburg, Sweden4 aut0 (Swepub:gu)xpalla |
700 | 1 | a Stockelberg, Dick,d 1950u Sahlgrens University Hospital, Sweden4 aut0 (Swepub:gu)xstodi |
700 | 1 | a Wei, Yuan,d 1978u Sahlgrens University Hospital, Sweden4 aut0 (Swepub:gu)xweiyu |
700 | 1 | a Gréen, Henriku Linköpings universitet,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Avdelningen för läkemedelsforskning,Hälsouniversitetet,KTH Royal Institute Technology, Sweden4 aut0 (Swepub:liu)hengr89 |
700 | 1 | a Lotfi, Kouroshu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,Klinisk farmakologi4 aut0 (Swepub:liu)koulo97 |
710 | 2 | a Linköpings universitetb Avdelningen för läkemedelsforskning4 org |
773 | 0 | t British Journal of Haematologyd : Wileyg 167:5, s. 671-680q 167:5<671-680x 0007-1048x 1365-2141 |
856 | 4 | u http://liu.diva-portal.org/smash/get/diva2:779143/FULLTEXT01 |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:779143/FULLTEXT01.pdfx primaryx Raw objecty fulltext:postprint |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-158806 |
856 | 4 8 | u https://doi.org/10.1111/bjh.13097 |
856 | 4 8 | u https://gup.ub.gu.se/publication/206475 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-112996 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130134492 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-239739 |
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