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Sökning: onr:"swepub:oai:DiVA.org:kth-158941" > Plasma profiling re...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004146naa a2200445 4500
001oai:DiVA.org:kth-158941
003SwePub
008150115s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1589412 URI
0247 a https://doi.org/10.1002/acn3.832 DOI
040 a (SwePub)kth
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Häggmark, Annau KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1g5roxd
2451 0a Plasma profiling revelas three proteins associated to amyotrophic lateral sclerosis
264 c 2014-07-14
264 1b Wiley,c 2014
338 a electronic2 rdacarrier
500 a QC 20150115
520 a OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is the most common adult motor neuron disease leading to muscular paralysis and death within 3-5 years from onset. Currently, there are no reliable and sensitive markers able to substantially shorten the diagnosis delay. The objective of the study was to analyze a large number of proteins in plasma from patients with various clinical phenotypes of ALS in search for novel proteins or protein profiles that could serve as potential indicators of disease.METHODS: Affinity proteomics in the form of antibody suspension bead arrays were applied to profile plasma samples from 367 ALS patients and 101 controls. The plasma protein content was directly labeled and protein profiles obtained using 352 antibodies from the Human Protein Atlas targeting 278 proteins. A focused bead array was then built to further profile eight selected protein targets in all available samples.RESULTS: Disease-associated significant differences were observed and replicated for profiles from antibodies targeting the proteins: neurofilament medium polypeptide (NEFM), solute carrier family 25 (SLC25A20), and regulator of G-protein signaling 18 (RGS18).INTERPRETATION: Upon further validation in several independent cohorts with inclusion of a broad range of other neurological disorders as controls, the alterations of these three protein profiles in plasma could potentially provide new molecular markers of disease that contribute to the quest of understanding ALS pathology.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomedicinsk laboratorievetenskap/teknologi0 (SwePub)304022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomedical Laboratory Science/Technology0 (SwePub)304022 hsv//eng
7001 a Mikus, Mariau KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1qjoszn
7001 a Mohsenchian, Atefehu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1nf4uzu
7001 a Hong, Mun-Gwanu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u19gmsru
7001 a Forsström, Björnu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u11i5nju
7001 a Gajewska, Beata4 aut
7001 a Baranczyk-Kuzma, Anna4 aut
7001 a Uhlén, Mathiasu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1dulvmw
7001 a Schwenk, Jochen M.u KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1h7wtme
7001 a Kuzma-Kozakiewicz, Magdalena4 aut
7001 a Nilsson, Peteru KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ws88sk
7102 a KTHb Proteomik och nanobioteknologi4 org
7730 t Annals of Clinical and Translational Neurologyd : Wileyg 1:8, s. 544-553q 1:8<544-553x 2328-9503
8564 u https://kth.diva-portal.org/smash/get/diva2:780956/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.83
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-158941
8564 8u https://doi.org/10.1002/acn3.83

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