Sökning: onr:"swepub:oai:DiVA.org:kth-16280" >
Association of rena...
Association of renal Na,K-ATPase alpha-subunit with the beta- and gamma-subunits based on cryoelectron microscopy
-
- Purhonen, P. (författare)
- Karolinska Institutet
-
Thomsen, K. (författare)
-
Maunsbach, A. B. (författare)
-
visa fler...
-
- Hebert, Hans (författare)
- Karolinska Institutet,KTH,Strukturell bioteknik
-
visa färre...
-
(creator_code:org_t)
- 2007-06-06
- 2006
- Engelska.
-
Ingår i: Journal of Membrane Biology. - : Springer Science and Business Media LLC. - 0022-2631 .- 1432-1424. ; 214:3, s. 139-146
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Na,K-ATPase transports Na+ and K+ across cell membranes and consists of alpha- and beta-subunits. Na,K-ATPase also associates with small FXYD proteins that regulate the activity of the pump. We have used cryoelectron microscopy of two-dimensional crystals including data to 8 A resolution to determine the three-dimensional (3-D) structure of renal Na,K-ATPase containing FXYD2, the gamma-subunit. A homology model for the a- subunit was calculated from a Ca2+-ATPase structure and used to locate the additional beta- and gamma-subunits present in the 3-D map of Na,K-ATPase. Based on the 3-D map, the beta- subunit is located close to transmembrane helices M8 and M10 and the gamma-subunit is adjacent to helices M2 and M9 of the alpha-subunit.
Nyckelord
- Na
- K-ATPase
- cryoelectron microscopy
- gamma-subunit
- beta-subunit
- FXYD2
- calcium-pump
- crystal-structure
- 3-dimensional structure
- sarcoplasmic-reticulum
- cross-links
- atpase
- resolution
- binding
- domain
- ca2+-atpase
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas