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Myocardial angiogen...
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Hao, Xiaojin
(författare)
Myocardial angiogenesis after plasmid or adenoviral VEGF-A(165) gene transfer in rat myocardial infarction model
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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Oxford University Press (OUP),2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:kth-16381
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-16381URI
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https://doi.org/10.1016/j.cardiores.2006.10.011DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1956218URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20100525
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Objective: To compare gene transfer of plasmid (P) and adenovirus (Ad) encoding human vascular endothelial growth factor-A(165) (hVEGF-A(165)) angiogenic efficacy and adverse effects as regards apoptosis and ectopic expression of the transgene in a rat myocardial infarction model. Methods: Myocardial infarction was provoked in Fisher rats. One week later, PhVEGF-A(165), PLacZ, AdhVEGF-A(165), or AdLacZ was transferred intramyocardially along the border of the myocardial infarction. hVEGF-A expression was detected with ELISA. Myocardial vessel density was analyzed 1 and 4 weeks after gene transfer. Apoptosis was detected by TUNEL staining. Cardiac function was assessed with Tissue Doppler Velocity Imaging. Results: Although AdhVEGF-A(165) had substantially higher myocardial hVEGF-A expression than PhVEGF-A(165), AdhVEGF-A(165) and PhVEGF-A(165) induced angiogenic effects to a similar extent with maintained increased arteriolar density after 4 weeks of gene transfer (p < 0.05). The two treatments also improved left ventricular function similarly. Adenoviral gene transfer induced a higher number of TUNEL positive cells than plasmid (p < 0.02). Ectopic expression of the transgene was present with both vectors but substantially higher after adenoviral gene transfer. Conclusions: AdhVEGF-A165 has no obvious angiogenic advantage over PhVEGF-A165 but more side effects at least in a rat myocardial infarction model. This indicates that PhVEGF-A(165) might be more applicable for therapeutic angiogenesis than AdhVEGF-A(165).
Ämnesord och genrebeteckningar
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angiogenesis
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gene therapy
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infarction
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growth factors
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apoptosis
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endothelial growth-factor
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expression
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ischemia
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vectors
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feasibility
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mechanisms
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apoptosis
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therapy
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artery
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trial
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mansson-Broberg, AgnetaKarolinska Institutet
(författare)
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Grinnemo, Karl-HenrikKarolinska Institutet
(författare)
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Siddiqui, Anwar J.Karolinska Institutet
(författare)
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Dellgren, Goran
(författare)
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Brodin, Lars-ÅkeKarolinska Institutet(Swepub:kth)u1jq9s27
(författare)
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Sylven, ChristerKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cardiovascular Research: Oxford University Press (OUP)73:3, s. 481-4870008-63631755-3245
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