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Potential genetic v...
Potential genetic variants in schizophrenia : A Bayesian analysis
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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2009-07-12
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Informa UK Limited,2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:kth-16438
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-16438URI
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https://doi.org/10.1080/15622970600892004DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:11983389URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20100525
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A number of different gene polymorphisms have been found to dispose for the development of schizophrenia. However, no single gene polymorphism is sufficient for the precipitation of schizophrenia. Swedish psychosis patients (n = 103) and control subjects (n = 89) were analyzed for 36 single nucleotide polymorphisms in 30 candidate genes for schizophrenia. Evidence of association was analyzed with Bayesian statistical methods. Variants in the genes coding for dopamine-D-2 receptor, brain-derived neurotrophic factor (BDNF), neuropeptide Y (NPY), neuregulin 1, reelin and synapsin 3 showed association with schizophrenia, although few subjects were found in the minority allele for the two latter variants. The six gene variants, all with suspected connection to schizophrenia, were found to be risk factors when considered in combination, but not separately. The results indicate that the Bayesian statistical method gives additional possibilities in the search for risk factors for schizophrenia or other complex disorders.
Ämnesord och genrebeteckningar
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BDNE
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dopamine-D2 receptor
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neuregulin 1
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neuropeptide Y
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schizophrenia
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d2 receptor gene
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neuropeptide-y polymorphism
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brain morphology
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bdnf gene
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association
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metaanalysis
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expression
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risk
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population
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alleles
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lawyer, Glenn
(författare)
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Sillen, AnnaKarolinska Institutet
(författare)
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Jonsson, Erik G.Karolinska Institutet
(författare)
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Agartz, IngridKarolinska Institutet
(författare)
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Terenius, LarsKarolinska Institutet
(författare)
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Arnborg, StefanKTH,Numerisk Analys och Datalogi, NADA(Swepub:kth)u1i2fxfy
(författare)
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Karolinska InstitutetNumerisk Analys och Datalogi, NADA
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:World Journal of Biological Psychiatry: Informa UK Limited8:1, s. 12-221562-29751814-1412
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