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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03694naa a2200553 4500 | |
| 001 | oai:DiVA.org:kth-186765 | |
| 003 | SwePub | |
| 008 | 160513s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1867652 URI |
| 024 | 7 | a https://doi.org/10.1002/jbm.a.357412 DOI |
| 040 | a (SwePub)kth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Yassin, M. A.4 aut |
| 245 | 1 0 | a Surfactant tuning of hydrophilicity of porous degradable copolymer scaffolds promotes cellular proliferation and enhances bone formation |
| 264 | c 2016-04-19 | |
| 264 | 1 | b John Wiley & Sons,c 2016 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20160627 | |
| 520 | a Poly(l-lactide-co-e(open)-caprolactone) (poly(LLA-co-CL)) has been blended with Tween 80 to tune the material properties and optimize cell-material interactions. Accordingly, the aims of this study were fourfold: to evaluate the effect of low concentrations of Tween 80 on the surface microstructure of 3D poly(LLA-co-CL) porous scaffolds: to determine the effect of different concentrations of Tween 80 on proliferation of bone marrow stromal cells (BMSCs) in vitro under dynamic cell culture at 7 and 21 days; to assess the influence of Tween 80 on the degradation rate of poly(LLA-co-CL) at 7 and 21 days; and in a subcutaneous rat model, to evaluate the effect on bone formation of porous scaffolds modified with 3% Tween 80 at 2 and 8 weeks. Blending 3% (w/w) Tween 80 with poly(LLA-co-CL) improves the surface wettability (p<0.001). Poly(LLA-co-CL)/3% Tween 80 shows significantly increased cellular proliferation at days 7 and 21 (p<0.001). Moreover, the presence of Tween 80 facilitates the degradation of poly(LLA-co-CL). Two weeks post-implantation, the poly(LLA-co-CL)/3% Tween 80 scaffolds exhibit significant mRNA expression of Runx2 (p=0.004). After 8 weeks, poly(LLA-co-CL)/3% Tween 80 scaffolds show significantly increased de novo bone formation, demonstrated by μ-CT (p=0.0133) and confirmed histologically. It can be concluded that blending 3% (w/w) Tween 80 with poly (LLA-co-CL) improves the hydrophilicity and osteogenic potential of the scaffolds. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomedicinsk laboratorievetenskap/teknologi0 (SwePub)304022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomedical Laboratory Science/Technology0 (SwePub)304022 hsv//eng |
| 653 | a BMSCs | |
| 653 | a Bone formation | |
| 653 | a Copolymer scaffolds | |
| 653 | a Hydrophilicity | |
| 653 | a Tween 80 | |
| 653 | a Blending | |
| 653 | a Bone | |
| 653 | a Cell culture | |
| 653 | a Cell proliferation | |
| 653 | a Degradation | |
| 653 | a Bone marrow stromal cells (BMSCs) | |
| 653 | a Cell-material interaction | |
| 653 | a Cellular proliferations | |
| 653 | a Surface microstructures | |
| 653 | a Scaffolds (biology) | |
| 700 | 1 | a Leknes, K. N.4 aut |
| 700 | 1 | a Sun, Yangu KTH,Fiber- och polymerteknologi4 aut0 (Swepub:kth)u1c2xym2 |
| 700 | 1 | a Lie, S. A.4 aut |
| 700 | 1 | a Finne-Wistrand, Annau KTH,Fiber- och polymerteknologi4 aut0 (Swepub:kth)u17gwfv7 |
| 700 | 1 | a Mustafa, K.4 aut |
| 710 | 2 | a KTHb Fiber- och polymerteknologi4 org |
| 773 | 0 | t Journal of Biomedical Materials Research. Part Ad : John Wiley & Sonsx 1549-3296x 1552-4965 |
| 856 | 4 | u https://bora.uib.no/bora-xmlui/bitstream/1956/15558/1/dr-thesis-2017-Mohammed-Ahmed-Alamin-Yousif-Yassin.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-186765 |
| 856 | 4 8 | u https://doi.org/10.1002/jbm.a.35741 |
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