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SUMOylation Mediate...
SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor
- Artikel/kapitelEngelska2010
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American Association for the Advancement of Science (AAAS),2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:kth-19315
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-19315URI
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https://doi.org/10.1126/scisignal.2000628DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-130552URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:120189210URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20120329
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The insulin-like growth factor 1 receptor (IGF-1R) plays crucial roles in developmental and cancer biology. Most of its biological effects have been ascribed to its tyrosine kinase activity, which propagates signaling through the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. Here, we report that IGF-1 promotes the modification of IGF-1R by small ubiquitin-like modifier protein-1 (SUMO-1) and its translocation to the nucleus. Nuclear IGF-1R associated with enhancer-like elements and increased transcription in reporter assays. The SUMOylation sites of IGF-1R were identified as three evolutionarily conserved lysine residues-Lys(1025), Lys(1100), and Lys(1120)-in the beta subunit of the receptor. Mutation of these SUMO-1 sites abolished the ability of IGF-1R to translocate to the nucleus and activate transcription, but did not alter its kinase-dependent signaling. Thus, we demonstrate a SUMOylation-mediated mechanism of IGF-1R signaling that has potential implications for gene regulation.
Ämnesord och genrebeteckningar
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growth-factor receptor
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insulin-receptor
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tyrosine kinase
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i receptor
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chromatin immunoprecipitation
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transcription factor
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sumo-1
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modification
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proximity ligation
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egf receptor
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protein
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MEDICINE
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Tofigh, AliKTH,Beräkningsbiologi, CB(Swepub:kth)u1jd3xga
(författare)
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Lin, YingboKarolinska Institutet
(författare)
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Trocme, EricKarolinska Institutet
(författare)
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Liljedahl, UlrikaUppsala universitet,Molekylär medicin(Swepub:uu)ullil257
(författare)
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Lagergren, JensKTH,Beräkningsbiologi, CB(Swepub:kth)u13fcyg9
(författare)
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Larsson, OlleKarolinska Institutet
(författare)
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KTHBeräkningsbiologi, CB
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Science Signaling: American Association for the Advancement of Science (AAAS)3:1081945-08771937-9145
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