Intrarenal dopamine coordinates the effect of antinatriuretic and natriuretic factors

• The precision by which sodium balance is regulated suggests an intricate interaction between modulatory factors released from intra- and extrarenal sources. Intrarenally produced dopamine has a central role in this interactive network. Dopamine, produced in renal tubular cells acts as an autocrine and paracrine factor to inhibit the activity of Na+,K+-ATPase as well as of a number of sodium influx pathways. The natriuretic effect of dopamine is most prominent under high salt diet. The antinatriuretic effects of noradrenaline, acting on alpha-adrenoceptors and angiotensin II are opposed by dopamine as well as by atrial natriuretic peptide (ANP). Several lines of evidence have suggested that ANP acts via the renal dopamine system and recent studies from our laboratory have shown that this effect is attributed to recruitment of silent D1 receptors from the interior of the cell towards the plasma membrane. Taken together, the observations suggest that dopamine coordinates the effects of antinatriuretic and natriuretic factors and indicate that an intact renal dopamine system is of major importance for the maintenance of sodium homeostasis and normal blood pressure.

Nyckelord

alpha-adrenoceptors

ANP (atrial natriuretic peptide)

catechol-O-methyltransferase

D1 like receptors

dopamine

hypertension

K+-ATPase

Na

natriuresis

proximal convoluted tubule

k+-atpase activity

adenylate-cyclase

receptor

hypertension

sodium

rat

stimulation

kidney

na+,k+-atpase

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)