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Catalyst-Free Cyclo...
Catalyst-Free Cycloaddition Reaction for the Synthesis of Glyconanoparticles
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- Kong, Na (författare)
- KTH,Kemi
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- Xie, Sheng (författare)
- KTH,Kemi
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- Zhou, Juan (författare)
- KTH,Kemi
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Menendez, Margarita (författare)
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Solis, Dolores (författare)
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Park, JaeHyeung (författare)
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- Proietti, Giampiero (författare)
- KTH,Kemi
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- Ramström, Olof (författare)
- KTH,Organisk kemi
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- Yan, Mingdi (författare)
- KTH,Organisk kemi,University of Massachusetts Lowell, United States
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(creator_code:org_t)
- 2016-10-06
- 2016
- Engelska.
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 8:41, s. 28136-28142
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A new conjugation method for the immobilization of carbohydrates on nanomaterials was demonstrated simply by mixing perfluorophenyl azide-functionalized silica nanoparticles (SNPs), an amine-derivatized carbohydrate, and phenylacetaldehyde under ambient conditions without any catalyst. The density of carbohydrates on the glyconanoparticles was determined using the quantitative F-19 NMR (F-19 qNMR) technique; for example, the density of D-mannose (Man) on Man-SNPs was 2.5 +/- 0.2 x 10(-16) nmol/nm(2). The glyconanoparticles retained their binding affinity and selectivity toward cognate lectins. The apparent dissociation constant of the glyconanoparticles was measured by a fluorescence competition assay, where the binding affinity of Man-SNPs was almost 4 orders of magnitude higher than that of Man with concanavalin A. Moreover, even with a ligand density of 2.6 times lower than Man-SNPs synthesized by the copper catalyzed azide-alkyne cycloaddition, the binding affinity of Man-SNPs prepared by the current method was more than 4 times higher.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- carbohydrates
- glyconanomaterials
- coupling chemistry
- perfluoroaryl azides
- F-19 qNMR
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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