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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04339naa a2200493 4500 | |
| 001 | oai:DiVA.org:kth-19735 | |
| 003 | SwePub | |
| 008 | 100810s2000 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-197352 URI |
| 024 | 7 | a https://doi.org/10.1152/jn.2000.83.5.25622 DOI |
| 040 | a (SwePub)kth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Dickson, C. T.4 aut |
| 245 | 1 0 | a Properties and role of I-h in the pacing of subthreshold oscillations in entorhinal cortex layer II neurons |
| 264 | 1 | b American Physiological Society,c 2000 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20100525 QC 20111229 | |
| 520 | a Various subsets of brain neurons express a hyperpolarization-activated inward current (I-h) that has been shown to be instrumental in pacing oscillatory activity at both a single-cell and a network level. A characteristic feature of the stellate cells (SCs) of entorhinal cortex (EC) layer II, those neurons giving rise to the main component of the perforant path input to the hippocampal formation, is their ability to generate persistent, Na+-dependent rhythmic subthreshold membrane potential oscillations, which are thought to be instrumental in implementing theta rhythmicity in the entorhinal-hippocampal network. The SCs also display a robust time-dependent inward rectification in the hyperpolarizing direction that may contribute to the generation of these oscillations. We performed whole cell recordings of SCs in in vitro slices to investigate the specific biophysical and pharmacological properties of the current underlying this inward rectification and to clarify its potential role in the genesis of the subthreshold oscillations. In voltage-clamp conditions, hyperpolarizing voltage steps evoked a slow, noninactivating inward current, which also deactivated slowly on depolarization. This current was identified as I-h because it was resistant to extracellular Ba2+, sensitive to Cs+, completely and selectively abolished by ZD7288, and carried by both Na+ and K+ ions. I-h in the SCs had an activation threshold and reversal potential at approximately -45 and -20 mV, respectively. Its half-activation voltage was -77 mV. Importantly, bath perfusion with ZD7288, but not Ba2+ gradually and completely abolished the subthreshold oscillations, thus directly implicating I-h in their generation. Using experimentally derived biophysical parameters for I-h and the low-threshold persistent Na+ current (I-NaP) present in the SCs, a simplified model of these neurons was constructed and their subthreshold electroresponsiveness simulated. This indicated that the interplay between I-NaP and I-h can sustain persistent subthreshold oscillations in SCs. I-NaP and I-h operate in a push-pull fashion where the delay in the activation/deactivation of I-h gives rise to the oscillatory process. | |
| 650 | 7 | a NATURVETENSKAPx Data- och informationsvetenskapx Bioinformatik0 (SwePub)102032 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Computer and Information Sciencesx Bioinformatics0 (SwePub)102032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a hyperpolarization-activated current | |
| 653 | a long-term potentiation | |
| 653 | a hippocampal theta-rhythm | |
| 653 | a voltage-clamp analysis | |
| 653 | a sino-atrial node | |
| 653 | a anomalous rectification | |
| 653 | a cation current | |
| 653 | a inward current | |
| 653 | a neocortical neurons | |
| 653 | a sinoatrial node | |
| 700 | 1 | a Magistretti, J.4 aut |
| 700 | 1 | a Shalinsky, M. H.4 aut |
| 700 | 1 | a Fransén, Erik,d 1962-u KTH,Numerisk analys och datalogi, NADA4 aut0 (Swepub:kth)u14yg0os |
| 700 | 1 | a Hasselmo, M. E.4 aut |
| 700 | 1 | a Alonso, A.4 aut |
| 710 | 2 | a KTHb Numerisk analys och datalogi, NADA4 org |
| 773 | 0 | t Journal of Neurophysiologyd : American Physiological Societyg 83:5, s. 2562-2579q 83:5<2562-2579x 0022-3077x 1522-1598 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-19735 |
| 856 | 4 8 | u https://doi.org/10.1152/jn.2000.83.5.2562 |
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