Synthesis and application of chiral P,N-ligands with pseudo-meso and pseudo-C-2 symmetry

• [GRAPHICS] Two diastereoisomeric P,N-ligands, (S,S)-1 and (R,S)-1, were synthesized and assessed in palladium-catalyzed allylic alkylations. With rac-1,3-diphenylpropenyl acetate as substrate, ligand (AS)-1, with pseudo-C-2 symmetry, exhibited higher reactivity and higher enantioselectivity than the pseudo-meso ligand (R,S)-1, whereas reversal reactivity and selectivity were observed with rac-3-cyclohexenyl acetate.

Nyckelord

catalyzed allylic alkylation

bidentate ligands

substitutions

complexes

oxazolines

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