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Solid nanofoams bas...
Solid nanofoams based on cellulose nanofibers and indomethacin—the effect of processing parameters and drug content on material structure
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- Bannow, J. (författare)
- KTH Royal Institute of Technology, Sweden
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- Benjamins, Jan-Willem (författare)
- RISE,Kemi och material
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- Wohlert, Jakob (författare)
- KTH,Fiber- och polymerteknologi,Wallenberg Wood Science Center,KTH Royal Institute of Technology, Sweden
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- Löbmann, K. (författare)
- University of Copenhagen, Denmark
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- Svagan, Anna J. (författare)
- KTH,Fiber- och polymerteknologi,Wallenberg Wood Science Center,KTH Royal Institute of Technology, Sweden
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(creator_code:org_t)
- Elsevier, 2017
- 2017
- Engelska.
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Ingår i: International Journal of Pharmaceutics. - : Elsevier. - 0378-5173 .- 1873-3476. ; 526:1-2, s. 291-299
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The unique colloidal properties of cellulose nanofibers (CNF), makes CNF a very interesting new excipient in pharmaceutical formulations, as CNF in combination with some poorly-soluble drugs can create nanofoams with closed cells. Previous nanofoams, created with the model drug indomethacin, demonstrated a prolonged release compared to films, owing to the tortuous diffusion path that the drug needs to take around the intact air-bubbles. However, the nanofoam was only obtained at a relatively low drug content of 21 wt% using fixed processing parameters. Herein, the effect of indomethacin content and processing parameters on the foaming properties was analysed. Results demonstrate that a certain amount of dissolved drug is needed to stabilize air-bubbles. At the same time, larger fractions of dissolved drug promote coarsening/collapse of the wet foam. The pendant drop/bubble profile tensiometry was used to verify the wet-foam stability at different pHs. The pH influenced the amount of solubilized drug and the processing-window was very narrow at high drug loadings. The results were compared to real foaming-experiments and solid state analysis of the final cellular solids. The parameters were assembled into a processing chart, highlighting the importance of the right combination of processing parameters (pH and time-point of pH adjustment) in order to successfully prepare cellular solid materials with up to 46 wt% drug loading.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering (hsv//eng)
Nyckelord
- Cellular solid material
- Cellulose nanofibers
- Indomethacin
- Nanofoam
- Poorly-soluble drugs
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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