Sökning: onr:"swepub:oai:DiVA.org:kth-211610" > Anti-citrullinated ...
Fältnamn | Indikatorer | Metadata |
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000 | 07526naa a2200661 4500 | |
001 | oai:DiVA.org:kth-211610 | |
003 | SwePub | |
008 | 170811s2017 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:139909947 | |
009 | oai:DiVA.org:liu-144204 | |
009 | oai:DiVA.org:uu-331243 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2116102 URI |
024 | 7 | a https://doi.org/10.1172/jci.insight.936882 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1399099472 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1442042 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3312432 URI |
040 | a (SwePub)kthd (SwePub)kid (SwePub)liud (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ge, Changrong Pu Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sect Med Inflammat Res, Dept Med Biochem & Biophys, Stockholm, Sweden.4 aut |
245 | 1 0 | a Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage |
264 | 1 | b AMER SOC CLINICAL INVESTIGATION INC,c 2017 |
338 | a print2 rdacarrier | |
500 | a QC 20170811 | |
520 | a Today, it is known that autoimmune diseases start a long time before clinical symptoms appear. Anti-citrullinated protein antibodies (ACPAs) appear many years before the clinical onset of rheumatoid arthritis (RA). However, it is still unclear if and how ACPAs are arthritogenic. To better understand the molecular basis of pathogenicity of ACPAs, we investigated autoantibodies reactive against the C1 epitope of collagen type II (CII) and its citrullinated variants. We found that these antibodies are commonly occurring in RA. A mAb (ACC1) against citrullinated C1 was found to cross-react with several noncitrullinated epitopes on native CII, causing proteoglycan depletion of cartilage and severe arthritis in mice. Structural studies by X-ray crystallography showed that such recognition is governed by a shared structural motif "RG-TG" within all the epitopes, including electrostatic potential-controlled citrulline specificity. Overall, we have demonstrated a molecular mechanism that explains how ACPAs trigger arthritis. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
700 | 1 | a Tong, Dongmei Ru Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Southern Medical University, Guangzhou, China.,Karolinska Inst, Sect Med Inflammat Res, Dept Med Biochem & Biophys, Stockholm, Sweden.;Southern Med Univ, Dept Pathophysiol, Key Lab Shock & Microcirculat Res Guangdong, Guangzhou, Guangdong, Peoples R China.4 aut |
700 | 1 | a Liang, Bibo Tu Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm,Southern Medical University, Guangzhou, China,Karolinska Inst, Sect Med Inflammat Res, Dept Med Biochem & Biophys, Stockholm, Sweden.;Southern Med Univ, Dept Pathophysiol, Key Lab Shock & Microcirculat Res Guangdong, Guangzhou, Guangdong, Peoples R China.4 aut |
700 | 1 | a Lonnblom, Erik Su Karolinska Institutet,Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm,Karolinska Inst, Sect Med Inflammat Res, Dept Med Biochem & Biophys, Stockholm, Sweden.4 aut |
700 | 1 | a Schneider, Nadine Ku University Hospital Frankfurt Goethe University, Frankfurt, Germany,Goethe Univ, Fraunhofer Inst Mol Biol & Appl Ecol IME, Project Grp Translat Med & Pharmacol, Frankfurt, Germany.;Goethe Univ, Div Rheumatol, Univ Hosp Frankfurt, Frankfurt, Germany.4 aut |
700 | 1 | a Hagert, Cecilia Uu University of Turku, Finland,Univ Turku, Medicity Res Lab, Turku, Finland.;Natl Doctoral Programme Informat & Struct Biol, Turku, Finland.4 aut |
700 | 1 | a Viljanen, Johan V.u Uppsala universitet,Organisk kemi4 aut0 (Swepub:uu)johvi609 |
700 | 1 | a Ayoglu, Burcuu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Institute of Technology, Stockholm, Sweden,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, Affin Prote, Stockholm, Sweden.4 aut0 (Swepub:kth)u1kfjubd |
700 | 1 | a Stawikowska, Roma Tu Florida Atlantic University, Jupiter, Florida, USA,Florida Atlantic Univ, Dept Chem & Biochem, Jupiter, FL USA.4 aut |
700 | 1 | a Nilsson, Peter C.u KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Institute of Technology, Stockholm, Sweden,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, Affin Prote, Stockholm, Sweden.4 aut0 (Swepub:kth)u1ws88sk |
700 | 1 | a Fields, Gregg Bu Florida Atlantic University, Jupiter, Florida, USA,Florida Atlantic Univ, Dept Chem & Biochem, Jupiter, FL USA.4 aut |
700 | 1 | a Skogh, Thomasu Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland,Linkoping Univ, Dept Rheumatol, Dept Clin & Expt Med, Linkoping, Sweden.4 aut0 (Swepub:liu)thosk00 |
700 | 1 | a Kastbom, Alfu Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland,Linkoping Univ, Dept Rheumatol, Dept Clin & Expt Med, Linkoping, Sweden.4 aut0 (Swepub:liu)alfka05 |
700 | 1 | a Kihlberg, Janu Uppsala universitet,Organisk kemi4 aut0 (Swepub:uu)janki643 |
700 | 1 | a Burkhardt, Harald Tu University Hospital Frankfurt Goethe University, Frankfurt, Germany,Goethe Univ, Fraunhofer Inst Mol Biol & Appl Ecol IME, Project Grp Translat Med & Pharmacol, Frankfurt, Germany.;Goethe Univ, Div Rheumatol, Univ Hosp Frankfurt, Frankfurt, Germany.4 aut |
700 | 1 | a Dobritzsch, Doreen,d 1972-u Uppsala universitet,Biokemi,Structural Biochemistry4 aut0 (Swepub:uu)dordo526 |
700 | 1 | a Holmdahl, Rikard Ku Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden; University of Turku, Turku, Finland, Southern Medical University, Guangzhou, China,Karolinska Inst, Sect Med Inflammat Res, Dept Med Biochem & Biophys, Stockholm, Sweden.;Univ Turku, Medicity Res Lab, Turku, Finland.;Natl Doctoral Programme Informat & Struct Biol, Turku, Finland.;Southern Med Univ, Ctr Med Immunopharmacol Res, Guangzhou, Guangdong, Peoples R China.4 aut |
700 | 1 | a Ge, CRu Karolinska Institutet4 aut |
700 | 1 | a Tong, DMu Karolinska Institutet4 aut |
700 | 1 | a Liang, BB4 aut |
710 | 2 | a Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Swedenb Karolinska Inst, Sect Med Inflammat Res, Dept Med Biochem & Biophys, Stockholm, Sweden.4 org |
773 | 0 | t JCI INSIGHTd : AMER SOC CLINICAL INVESTIGATION INCg 2:13q 2:13x 2379-3708 |
856 | 4 | u http://insight.jci.org/articles/view/93688/files/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-211610 |
856 | 4 8 | u https://doi.org/10.1172/jci.insight.93688 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139909947 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-144204 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-331243 |
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