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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03735naa a2200577 4500 | |
| 001 | oai:DiVA.org:kth-21300 | |
| 003 | SwePub | |
| 008 | 100810s2002 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-213002 URI |
| 024 | 7 | a https://doi.org/10.1523/JNEUROSCI.22-03-01081.20022 DOI |
| 040 | a (SwePub)kth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Fransén, Erik,d 1962-u KTH,Numerisk analys och datalogi, NADA4 aut0 (Swepub:kth)u14yg0os |
| 245 | 1 0 | a Simulations of the role of the muscarinic-activated calcium-sensitive nonspecific cation current I-NCM in entorhinal neuronal activity during delayed matching tasks |
| 264 | 1 | c 2002 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20100525 | |
| 520 | a Entorhinal lesions impair performance in delayed matching tasks, and blockade of muscarinic cholinergic receptors also impairs performance in these tasks. Physiological data demonstrate that muscarinic cholinergic receptor stimulation activates intrinsic cellular currents in entorhinal neurons that could underlie the role of entorhinal cortex in performance of these tasks. Here we use a network biophysical simulation of the entorhinal cortex to demonstrate the potential role of this cellular mechanism in the behavioral tasks. Simulations demonstrate how the muscarinic-activated calcium-sensitive nonspecific cation current I-NCM could provide a cellular mechanism for features of the neuronal activity observed during performance of delayed matching tasks. In particular, I-NCM could underlie (1) the maintenance of sustained spiking activity during the delay period, (2) the enhancement of spiking activity during the matching period relative to the sample period, and (3) the resistance of sustained activity to distractors. Simulation of a larger entorhinal network with connectivity chosen randomly within constraints on number, distribution, and weight demonstrates appearance of other phenomena observed in unit recordings from awake animals, including match suppression, non-match enhancement, and non-match suppression. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Data- och informationsvetenskapx Bioinformatik0 (SwePub)102032 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Computer and Information Sciencesx Bioinformatics0 (SwePub)102032 hsv//eng |
| 653 | a delayed match to sample | |
| 653 | a delayed non-match | |
| 653 | a stellate cells | |
| 653 | a pyramidal cells | |
| 653 | a medial entorhinal cortex | |
| 653 | a afterhyperpolarization | |
| 653 | a working memory | |
| 653 | a biophysical modeling | |
| 653 | a computer simulation | |
| 653 | a nonspecific cationic current I-NCM | |
| 653 | a short-term-memory | |
| 653 | a cortex layer-ii | |
| 653 | a visual recognition memory | |
| 653 | a inferior temporal cortex | |
| 653 | a rat-association cortex | |
| 653 | a prefrontal cortex | |
| 653 | a differential electroresponsiveness | |
| 653 | a subthreshold oscillations | |
| 653 | a pyramidal neurons | |
| 653 | a perirhinal cortex | |
| 700 | 1 | a Alonso, A. A.4 aut |
| 700 | 1 | a Hasselmo, M. E.4 aut |
| 710 | 2 | a KTHb Numerisk analys och datalogi, NADA4 org |
| 773 | 0 | t Journal of Neuroscienceg 22:3, s. 1081-1097q 22:3<1081-1097x 0270-6474x 1529-2401 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-21300 |
| 856 | 4 8 | u https://doi.org/10.1523/JNEUROSCI.22-03-01081.2002 |
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