Sensitivity to interstimulus interval due to calcium interactions in the Purkinje cell spines

• Pairing specific LTD (PSD) is produced by paired parallel fiber (PF) and climbing fiber (CF) stimulation and requires Ca2+ elevation. CF or PF activation cause Ca2+ increase through voltage dependent channels and IP3 induced Ca2+ release, respectively. We developed a model of Ca2+ dynamics in Purkinje cell spines to investigate why paired PF-CF activation is necessary for PSD. Simulations show a supralinear increase of the Ca2+ signal if the CF input occurs in a restricted time interval following the PF input. Ca2- buffers significantly contribute to this phenomenon. This mechanism may be involved in the requirement of temporal specificity in classical conditioning.

Nyckelord

classical conditioning

Purkinje cells

IP3 induced Ca2+ release

Ca2+ buffers

LTD

long-term depression

neurons

ca2

insp(3)

release

rabbit

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)