Sökning: onr:"swepub:oai:DiVA.org:kth-21817" > Dissection of trans...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 02759naa a2200481 4500 | |
001 | oai:DiVA.org:kth-21817 | |
003 | SwePub | |
008 | 100810s2002 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-218172 URI |
024 | 7 | a https://doi.org/10.1091/mbc.E02-02-00752 DOI |
040 | a (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Koerkamp, M. G.4 aut |
245 | 1 0 | a Dissection of transient oxidative stress response in Saccharomyces cerevisiae by using DNA microarrays |
264 | 1 | c 2002 |
338 | a print2 rdacarrier | |
500 | a QC 20100525 | |
520 | a Yeast cells were grown in glucose-limited chemostat cultures and forced to switch to a new carbon source, the fatty acid oleate. Alterations in gene expression were monitored using DNA microarrays combined with bioinformatics tools, among which was included the recently developed algorithm REDUCE. Immediately after the switch to oleate, a transient and very specific stress response was observed, followed by the up-regulation of genes encoding peroxisomal enzymes required for fatty acid metabolism. The stress response included up-regulation of genes coding for enzymes to keep thioredoxin and glutathione reduced, as well as enzymes required for the detoxification of reactive oxygen species. Among the genes coding for various isoenzymes involved in these processes, only a specific subset was expressed. Not the general stress transcription factors Msn2 and Msn4, but rather the specific factor Yap1p seemed to be the main regulator of the stress response. We ascribe the initiation of the oxidative stress response to a combination of poor redox flux and fatty acid-induced uncoupling of the respiratory chain during the metabolic reprogramming phase. | |
653 | a old-yellow enzyme | |
653 | a gene-expression | |
653 | a transcription factors | |
653 | a peroxisome proliferation | |
653 | a hydrogen-peroxide | |
653 | a binding protein | |
653 | a fatty-acids | |
653 | a yeast | |
653 | a induction | |
653 | a genome | |
700 | 1 | a Rep, M.4 aut |
700 | 1 | a Bussemaker, H. J.4 aut |
700 | 1 | a Hardy, Gpma4 aut |
700 | 1 | a Mul, A.4 aut |
700 | 1 | a Piekarska, K.4 aut |
700 | 1 | a Al-Khalili Szigyarto, Cristinau KTH,Bioteknologi4 aut0 (Swepub:kth)u1c02mh9 |
700 | 1 | a de Mattos, J. M. T.4 aut |
700 | 1 | a Tabak, H. F.4 aut |
710 | 2 | a KTHb Bioteknologi4 org |
773 | 0 | t Molecular Biology of the Cellg 13:8, s. 2783-2794q 13:8<2783-2794x 1059-1524x 1939-4586 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-21817 |
856 | 4 8 | u https://doi.org/10.1091/mbc.E02-02-0075 |
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