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Subcellular interac...
Subcellular interactions between parallel fibre and climbing fibre signals in Purkinje cells predict sensitivity of classical conditioning to interstimulus interval
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- Hellgren Kotaleski, Jeanette (författare)
- KTH,Numerisk analys och datalogi, NADA
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Lester, D. (författare)
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Blackwell, K. T. (författare)
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: Integrative Physiological & Behavioral Science. - 1053-881X .- 2168-7846. ; 37:4, s. 265-292
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Classical conditioning of the nictitating membrane response requires a specific temporal interval between conditioned stimulus and unconditioned stimulus, and produces an increase in Protein Kinase C (PKC) activation in Purkinje cells. To evaluate whether biochemical interactions within the Purkinje cell may explain the temporal sensitivity, a model of PKC activation by Ca2+, diacylglycerol (DAG), and arachidonic acid (AA) is developed. Ca2+ elevation is due to CF stimulation and IP3 induced Ca2+ release (IICR). DAG and IP3 result from PF stimulation, while AA results from phospholipase A2 (PLA(2)). Simulations predict increased PKC activation when PF stimulation precedes CF stimulation by 0.1 to 3 s. The sensitivity of IICR to the temporal relation between PF and CF stimulation, together with the buffering system of Purkinje cells, significantly contribute to the temporal sensitivity.
Nyckelord
- classical conditioning
- Purkinje cell
- protein kinase C
- IP3 induced calcium release
- computer modeling
- LTD
- long-term depression
- inositol 1,4,5-trisphosphate
- calcium
- membrane
- range
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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