Sökning: onr:"swepub:oai:DiVA.org:kth-224455" > Chemoenzymatic Appr...
Fältnamn | Indikatorer | Metadata |
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000 | 03244naa a2200517 4500 | |
001 | oai:DiVA.org:kth-224455 | |
003 | SwePub | |
008 | 180318s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2244552 URI |
024 | 7 | a https://doi.org/10.1002/adsc.2017014852 DOI |
040 | a (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Marx, Lisau KTH,Industriell bioteknologi4 aut0 (Swepub:kth)u1pllep3 |
245 | 1 0 | a Chemoenzymatic Approaches to the Synthesis of the Calcimimetic Agent Cinacalcet Employing Transaminases and Ketoreductases |
264 | c 2018-02-28 | |
264 | 1 | b Wiley-VCH Verlagsgesellschaft,c 2018 |
338 | a print2 rdacarrier | |
500 | a QC 20180326 | |
520 | a Abstract Several chemoenzymatic routes have been explored for the preparation of cinacalcet, a calcimimetic agent. Transaminases (TAs) and ketoreductases (KREDs) turned out to be useful biocatalysts for the preparation of key optically active precursors. Thus, the asymmetric amination of 1âacetonaphthone yielded an enantiopure (R)âamine, which can be alkylated in one step to yield cinacalcet. Alternatively, the bioreduction of the same ketone resulted in an enantiopure (S)âalcohol, which was easily converted into the previous (R)âamine. In addition, the reduction was efficiently performed with the KRED and its cofactor coâimmobilized on the same porous surface. This selfâsufficient heterogeneous biocatalyst presented an accumulated total turnover number (TTN) for the cofactor of 675 after 5 consecutive operational cycles. Finally, in a preparative scale synthesis the TAâbased approach was performed in aqueous medium and led to enantiopure cinacalcet in two steps and 50% overall yield. | |
650 | 7 | a TEKNIK OCH TEKNOLOGIERx Industriell bioteknikx Biokatalys och enzymteknik0 (SwePub)209062 hsv//swe |
650 | 7 | a ENGINEERING AND TECHNOLOGYx Industrial Biotechnologyx Biocatalysis and Enzyme Technology0 (SwePub)209062 hsv//eng |
653 | a Cinacalcet | |
653 | a Transaminases | |
653 | a Ketoreductases | |
653 | a Asymmetric synthesis | |
653 | a Biocatalysis | |
653 | a Bioteknologi | |
653 | a Biotechnology | |
700 | 1 | a Rios-Lombardia, Nicolas4 aut |
700 | 1 | a Farnberger, Judith F.4 aut |
700 | 1 | a Kroutil, Wolfgang4 aut |
700 | 1 | a Benitez-Mateos, Ana I.4 aut |
700 | 1 | a Lopez-Gallego, Fernando4 aut |
700 | 1 | a Moris, Francisco4 aut |
700 | 1 | a Gonzalez-Sabin, Javier4 aut |
700 | 1 | a Berglund, Peru KTH,Industriell bioteknologi4 aut0 (Swepub:kth)u1271chh |
710 | 2 | a KTHb Industriell bioteknologi4 org |
773 | 0 | t Advanced Synthesis and Catalysisd : Wiley-VCH Verlagsgesellschaftg 360:11, s. 2157-2165q 360:11<2157-2165x 1615-4150x 1615-4169 |
856 | 4 | u https://doi.org/10.1002/adsc.201701485y Fulltext |
856 | 4 | u https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.201701485 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adsc.201701485 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-224455 |
856 | 4 8 | u https://doi.org/10.1002/adsc.201701485 |
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