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Targeted and imagin...
Targeted and imaging-guided in vivo photodynamic therapy for tumors using dual-function, aggregation-induced emission nanoparticles
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- Sun, Xianhe (författare)
- Zhejiang Univ, Ctr Opt & Electromagnet Res, State Key Lab Modern Opt Instrumentat, Hangzhou 310058, Zhejiang, Peoples R China.
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- Zebibula, Abudureheman (författare)
- Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Urol, Coll Med, Hangzhou 310016, Zhejiang, Peoples R China.
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- Dong, Xiaobiao (författare)
- Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Labs Organ Solids & Analyt Chem Living Bi, Beijing 100190, Peoples R China.
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- Li, Gonghui (författare)
- Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Urol, Coll Med, Hangzhou 310016, Zhejiang, Peoples R China.
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- Zhang, Guanxin (författare)
- Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Labs Organ Solids & Analyt Chem Living Bi, Beijing 100190, Peoples R China.
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- Zhang, Deqing (författare)
- Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Labs Organ Solids & Analyt Chem Living Bi, Beijing 100190, Peoples R China.
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- Qian, Jun (författare)
- Zhejiang Univ, Ctr Opt & Electromagnet Res, State Key Lab Modern Opt Instrumentat, Hangzhou 310058, Zhejiang, Peoples R China.
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- He, Sailing (författare)
- KTH,Elektroteknisk teori och konstruktion,Zhejiang Univ, Ctr Opt & Electromagnet Res, State Key Lab Modern Opt Instrumentat, Hangzhou 310058, Zhejiang, Peoples R China.;Royal Inst Technol, Sch Elect Engn, OSQULDAS VAG 6, SE-10044 Stockholm, Sweden.
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Zhejiang Univ, Ctr Opt & Electromagnet Res, State Key Lab Modern Opt Instrumentat, Hangzhou 310058, Zhejiang, Peoples R China Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Urol, Coll Med, Hangzhou 310016, Zhejiang, Peoples R China. (creator_code:org_t)
- 2018-05-12
- 2018
- Engelska.
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Ingår i: Nano Reseach. - : Tsinghua University Press. - 1998-0124 .- 1998-0000. ; 11:5, s. 2756-2770
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Imaging-guided photodynamic therapy (PDT) has been regarded as a promising strategy for precise cancer treatment. Because of their excellent modifiability and drug-loading capacity, nanoparticles have played an important role in PDT. Nonetheless, when traditional photosensitizers are made into nanoparticles, both their fluorescence and reactive oxygen species generation efficacy decrease due to a phenomenon known as aggregation-caused quenching. Fortunately, in recent years, several kinds of organic dyes with "abnormal" properties (termed aggregation-induced emission, AIE) were developed. With enhanced fluorescence emission in the nanoaggregation state, the traditional obstacles mentioned above may be overcome by AIE luminogens. Herein, we provide a better combination of photosensitizers and nanoparticles, namely, dual-function AIE nanoparticles capable of producing reactive oxygen species, to implement targeted and imaging-guided in vivo PDT. Good contrast of in vivo imaging and obvious therapeutic efficacy were observed at a low dose of AIE nanoparticles and low irradiance of light, thus resulting in negligible side effects. Our work shows that AIE nanoparticles may play a promising role in imaging-guided clinical PDT for cancer in the near future.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- aggregation-induced emission
- targeted therapy
- imaging-guided therapy
- photodynamic therapy
- tumor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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