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A novel cysteine-li...
A novel cysteine-linked antibacterial surface coating significantly inhibits bacterial colonization of nasal silicone prongs in a phase one pre-clinical trial
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- Odeberg, Jacob (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,CytaCoat AB, Stockholm, Sweden.;Karolinska Inst, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Ctr Hematol, Stockholm, Sweden.
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- Wirsen, Anders (författare)
- CytaCoat AB, Stockholm, Sweden.
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- Norberg, Ake (författare)
- CytaCoat AB, Stockholm, Sweden.
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- Frie, Jakob (författare)
- Karolinska Institutet
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- Printz, Gordana (författare)
- Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
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- Lagercrantz, Hugo (författare)
- Karolinska Institutet
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- Gudmundsson, Gudmundur H. (författare)
- Karolinska Institutet
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- Agerberth, Birgitta (författare)
- Karolinska Institutet
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- Jonsson, Baldvin (författare)
- Karolinska Institutet
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(creator_code:org_t)
- ELSEVIER SCIENCE BV, 2018
- 2018
- Engelska.
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Ingår i: Materials science & engineering. C, biomimetic materials, sensors and systems. - : ELSEVIER SCIENCE BV. - 0928-4931 .- 1873-0191. ; 93, s. 782-789
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Ventilator associated pneumonia and sepsis are frequent complications in neonatal care. Bacterial colonization of medical devices and interfaces used for respiratory support may contribute by functioning as a bacterial reservoir seeding bacteria into airways. We have developed an antibacterial surface coating based on a cysteine ligand covalently coupled via a spacer to a carboxylic backbone layer on an acrylic acid grafted silicone surface. This coating was applied on a commercially available nasal prong and the antibacterial effect was evaluated both in vitro and in vivo in a first-in-human phase 1 trial. The coated nasal prongs had strong antibacterial activity against both Gram-negative and Gram-positive bacteria in vitro. In a randomized pre-clinical trial study of 24 + 24 healthy adult volunteers who carried coated or non-coated nasal prongs for 18 h, a (10)log difference in mean bacterial colonization of 5.82 (p < 0.0001) was observed. These results show that this coating technique can prevent colonization by the normal skin and mucosal flora, and thus represent a promising novel technology for reduction of medical device-associated hospital acquired infections.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Antibacterial coating
- Cysteine ligand
- Covalent binding
- Phase one trial
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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