The role of p53 codon 72 and human papilloma virus status of cutaneous squamous cell carcinoma in the Swedish population

• The arginine variant of the p53 codon 72 polymorphism as well as anogenital and epidermodysplasia verruciformis (EV) types of human papilloma virus (HPV) are suggested to confer increased risk for developing cutaneous squamous cell carcinoma (SCC). In this pilot study, we analysed the p53 codon 72 genotype distribution in 106 microdissected samples from normal and tumour tissues of 53 cases of cutaneous SCC and 96 controls from Sweden. Both normal and tumour samples from cases of SCC were screened for anogenital and EV HPV. The p53(Arg) allele was not associated with the development of cutaneous SCC. Anogenital HPV (44%) was more prevalent than EV HPV (12%). Data also indicate that anogenital HPV is more common in tumour samples, but HPV infection was not identified as a significant risk factor for developing SCC. The presence of anogenital HPV, but not EV HPV might be a risk factor for development of cutaneous SCC.

Nyckelord

single nucleotide polymorphism

loss of heterozygozity (LOH)

epidermodysplasia verruciformis (EV)

anogenital

nonmelanoma skin cancers

renal-transplant recipients

cervical-cancer

72 polymorphism

e6 proteins

immunocompetent individuals

induced apoptosis

hpv types

low-risk

susceptibility

Publikations- och innehållstyp

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