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Sexual dimorphism i...
Sexual dimorphism in the incidence of human cancers
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- Zheng, Daoshan (författare)
- Mayo Clin, Dept Canc Biol, 4500 San Pablo Rd,Griffin 210, Jacksonville, FL 32224 USA.
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- Trynda, Justyna (författare)
- Mayo Clin, Dept Canc Biol, 4500 San Pablo Rd,Griffin 210, Jacksonville, FL 32224 USA.
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- Williams, Cecilia, Professor, 1969- (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab
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- Vold, Jeremy A. (författare)
- Mayo Clin, Mayo Canc Registry, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
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- Nguyen, Justin H. (författare)
- Mayo Clin, Dept Surg, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.;Mayo Clin, Ctr Canc, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
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- Harnois, Denise M. (författare)
- Mayo Clin, Dept Surg, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.;Mayo Clin, Ctr Canc, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
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- Bagaria, Sanjay P. (författare)
- Mayo Clin, Dept Surg, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.;Mayo Clin, Ctr Canc, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
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- McLaughlin, Sarah A. (författare)
- Mayo Clin, Dept Surg, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.;Mayo Clin, Ctr Canc, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
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- Li, Zhaoyu (författare)
- Mayo Clin, Dept Canc Biol, 4500 San Pablo Rd,Griffin 210, Jacksonville, FL 32224 USA.
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Mayo Clin, Dept Canc Biol, 4500 San Pablo Rd,Griffin 210, Jacksonville, FL 32224 USA Science for Life Laboratory, SciLifeLab (creator_code:org_t)
- 2019-07-12
- 2019
- Engelska.
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Ingår i: BMC Cancer. - : BMC. - 1471-2407. ; 19:1
- Relaterad länk:
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https://bmccancer.bi...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundSex differences in the incidences of cancers become a critical issue in both cancer research and the development of precision medicine. However, details in these differences have not been well reported. We provide a comprehensive analysis of sexual dimorphism in human cancers.MethodsWe analyzed four sets of cancer incidence data from the SEER (USA, 1975-2015), from the Cancer Registry at Mayo Clinic (1970-2015), from Sweden (1970-2015), and from the World Cancer Report in 2012.ResultsWe found that all human cancers had statistically significant sexual dimorphism with male dominance in the United States and mostly significant in the Mayo Clinic, Sweden, and the world data, except for thyroid cancer, which is female-dominant.ConclusionsSexual dimorphism is a clear but mostly neglected phenotype for most human cancers regarding the clinical practice of cancer. We expect that our study will facilitate the mechanistic studies of sexual dimorphism in human cancers. We believe that fully addressing the mechanisms of sexual dimorphism in human cancers will greatly benefit current development of individualized precision medicine beginning from the sex-specific diagnosis, prognosis, and treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Sexual dimorphism
- Cancer incidence
- Human cancers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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