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Phenotypic Screen w...
Phenotypic Screen with the Human Secretome Identifies FGF16 as Inducing Proliferation of iPSC-Derived Cardiac Progenitor Cells
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- Jennbacken, Karin (författare)
- AstraZeneca, BioPharmaceut R&D, Biosci Cardiovasc, Cardiovasc,Renal & Metab,Res & Early Dev, S-43150 Molndal, Sweden.
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- Wagberg, Fredrik (författare)
- AstraZeneca, Mechanist Biol & Profiling, Discovery Sci, R&D, S-43150 Molndal, Sweden.
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- Karlsson, Ulla (författare)
- AstraZeneca, Mechanist Biol & Profiling, Discovery Sci, R&D, S-43150 Molndal, Sweden.
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- Eriksson, Jerry (författare)
- AstraZeneca, BioPharmaceut R&D, Biosci Cardiovasc, Cardiovasc,Renal & Metab,Res & Early Dev, S-43150 Molndal, Sweden.
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- Magnusson, Lisa (författare)
- AstraZeneca, BioPharmaceut R&D, Biosci Cardiovasc, Cardiovasc,Renal & Metab,Res & Early Dev, S-43150 Molndal, Sweden.
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- Chimienti, Marjorie (författare)
- AstraZeneca, BioPharmaceut R&D, Biosci Cardiovasc, Cardiovasc,Renal & Metab,Res & Early Dev, S-43150 Molndal, Sweden.
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- Ricchiuto, Piero (författare)
- AstraZeneca, R&D, Quantitat Biol, Discovery Sci, Cambridge CB4 0WG, England.
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- Bernstroem, Jenny (författare)
- AstraZeneca, R&D, Discovery Sci, Discovery Biol, S-43150 Molndal, Sweden.
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- Ding, Mei (författare)
- AstraZeneca, R&D, Discovery Sci, Discovery Biol, S-43150 Molndal, Sweden.
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- Ross-Thriepland, Douglas (författare)
- AstraZeneca, R&D, Discovery Sci, Discovery Biol, Cambridge CB4 0WG, England.
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- Xue, Yafeng (författare)
- AstraZeneca, R&D, Discovery Sci, Struct & Biophys & Fragment Screening, S-43150 Molndal, Sweden.
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- Peiris, Diluka (författare)
- Attana AB, S-11419 Stockholm, Sweden.
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- Aastrup, Teodor (författare)
- Attana AB, S-11419 Stockholm, Sweden.
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- Tegel, Hanna (författare)
- KTH,Proteinvetenskap
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- Hober, Sophia, 1965- (författare)
- KTH,Proteinteknologi
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- Sivertsson, Åsa (författare)
- KTH,Proteinvetenskap
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- Uhlén, Mathias (författare)
- KTH,Proteinvetenskap
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- Stroemstedt, Per-Erik (författare)
- AstraZeneca, Mechanist Biol & Profiling, Discovery Sci, R&D, S-43150 Molndal, Sweden.
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- Davies, Rick (författare)
- AstraZeneca, R&D, Discovery Sci, Discovery Biol, Cambridge CB4 0WG, England.
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- Holmberg Schiavone, Lovisa (författare)
- AstraZeneca, R&D, Discovery Sci, Discovery Biol, S-43150 Molndal, Sweden.
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AstraZeneca, BioPharmaceut R&D, Biosci Cardiovasc, Cardiovasc,Renal & Metab,Res & Early Dev, S-43150 Molndal, Sweden AstraZeneca, Mechanist Biol & Profiling, Discovery Sci, R&D, S-43150 Molndal, Sweden. (creator_code:org_t)
- 2019-11-30
- 2019
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 20:23
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Paracrine factors can induce cardiac regeneration and repair post myocardial infarction by stimulating proliferation of cardiac cells and inducing the anti-fibrotic, antiapoptotic, and immunomodulatory effects of angiogenesis. Here, we screened a human secretome library, consisting of 923 growth factors, cytokines, and proteins with unknown function, in a phenotypic screen with human cardiac progenitor cells. The primary readout in the screen was proliferation measured by nuclear count. From this screen, we identified FGF1, FGF4, FGF9, FGF16, FGF18, and seven additional proteins that induce proliferation of cardiac progenitor cells. FGF9 and FGF16 belong to the same FGF subfamily, share high sequence identity, and are described to have similar receptor preferences. Interestingly, FGF16 was shown to be specific for proliferation of cardiac progenitor cells, whereas FGF9 also proliferated human cardiac fibroblasts. Biosensor analysis of receptor preferences and quantification of receptor abundances suggested that FGF16 and FGF9 bind to different FGF receptors on the cardiac progenitor cells and cardiac fibroblasts. FGF16 also proliferated naive cardiac progenitor cells isolated from mouse heart and human cardiomyocytes derived from induced pluripotent cells. Taken together, the data suggest that FGF16 could be a suitable paracrine factor to induce cardiac regeneration and repair.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- human secretome
- phenotypic screening
- cardiac progenitor cells
- fibroblast growth factors
- fibroblast growth factor 16
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Jennbacken, Kari ...
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Wagberg, Fredrik
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Karlsson, Ulla
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Eriksson, Jerry
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Magnusson, Lisa
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Chimienti, Marjo ...
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visa fler...
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Ricchiuto, Piero
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Bernstroem, Jenn ...
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Ding, Mei
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Ross-Thriepland, ...
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Xue, Yafeng
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Peiris, Diluka
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Aastrup, Teodor
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Tegel, Hanna
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Hober, Sophia, 1 ...
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Sivertsson, Åsa
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Uhlén, Mathias
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Stroemstedt, Per ...
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Davies, Rick
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Holmberg Schiavo ...
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