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Periodontal Health ...
Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis
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- Eriksson, Kaja (författare)
- Karolinska Institutet
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- Fei, Guozhong (författare)
- Acad Specialist Ctr, Ctr Rheumatol, Stockholm Hlth Serv, S-10235 Stockholm, Sweden.,Center for Rheumatology, Academic Specialist Center, Stockholm Health Services, 10235 Stockholm, Sweden
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- Lundmark, Anna (författare)
- Karolinska Inst, Dept Dent Med, Div Periodontol, S-14104 Huddinge, Sweden.,Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, 14104 Huddinge, Sweden
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- Benchimol, Daniel (författare)
- Karolinska Institutet
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- Lee, Linkiat (författare)
- Karolinska Institutet
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- Hu, Yue O. O. (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Skolan för kemi, bioteknologi och hälsa (CBH),Science for Life Laboratory School of Biotechnology, KTH Royal Institute of Technology, 17121 Stockholm, Sweden; Department of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research (CTMR), Karolinska Institutet, 17164 Stockholm, Sweden
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- Kats, Anna (författare)
- Karolinska Inst, Dept Dent Med, Div Periodontol, S-14104 Huddinge, Sweden.,Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, 14104 Huddinge, Sweden
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- Saevarsdottir, Saedis (författare)
- Karolinska Institutet
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- Catrina, Anca Irinel (författare)
- Karolinska Institutet
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- Klinge, Björn (författare)
- Karolinska Institutet,Malmö universitet,Odontologiska fakulteten (OD),Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, 14104 Huddinge, Sweden
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- Andersson, Anders F. (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Skolan för kemi, bioteknologi och hälsa (CBH),Science for Life Laboratory School of Biotechnology, KTH Royal Institute of Technology, 17121 Stockholm, Sweden
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- Klareskog, Lars (författare)
- Karolinska Univ Hosp, Dept Med, Rheumatol Unit, S-17176 Stockholm, Sweden.,Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, 17176 Stockholm, Sweden
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- Lundberg, Karin (författare)
- Karolinska Institutet
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- Jansson, Leif (författare)
- Karolinska Inst, Dept Dent Med, Div Periodontol, S-14104 Huddinge, Sweden.;Stockholm Cty Council, Eastmaninst, Dept Periodontol, S-11382 Stockholm, Sweden.,Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, 14104 Huddinge, Sweden; Department of Periodontology at Eastmaninstitutet, Stockholm County Council, 11382 Stockholm, Sweden
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- Yucel-Lindberg, Tulay (författare)
- Karolinska Institutet
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Karolinska Institutet Acad Specialist Ctr, Ctr Rheumatol, Stockholm Hlth Serv, S-10235 Stockholm, Sweden (creator_code:org_t)
- 2019-05-08
- 2019
- Engelska.
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Ingår i: Journal of Clinical Medicine. - : MDPI AG. - 2077-0383. ; 8:5
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://mau.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection of blood, saliva, gingival crevicular fluid (GCF) and subgingival plaque. Composition of plaque and saliva microbiota were analysed using 16S rRNA sequencing and levels of inflammatory mediators by multiplex-immunoassay. The majority of the patients (75%) had moderate or severe periodontitis and the rest had no/mild periodontitis. Anti-citrullinated protein antibody (ACPA) positivity was significantly more frequent in the moderate/severe periodontitis (86%) compared to the no/mild group (50%). No significance between groups was observed for RA disease duration or activity, or type of medication. Levels of sCD30/TNFRSF8, IFN-2, IL-19, IL-26, MMP-1, gp130/sIL-6R ss, and sTNF-R1 were significantly higher in serum or GCF, and April/TNFSF13 was significantly higher in serum and saliva samples in moderate/severe periodontitis. The microbial composition in plaque also differed significantly between the two groups. In conclusion, the majority of RA patients had moderate/severe periodontitis and that this severe form of the disease was significantly associated with ACPA positivity, an altered subgingival microbial profile, and increased levels of systemic and oral inflammatory mediators.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- rheumatoid arthritis
- periodontitis
- periodontal disease
- anti-citrullinated protein autoantibodies
- rheumatoid factor
- smoking
- medication
- Porphyromonas gingivalis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Eriksson, Kaja
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Fei, Guozhong
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Lundmark, Anna
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Benchimol, Danie ...
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Lee, Linkiat
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Hu, Yue O. O.
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visa fler...
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Kats, Anna
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Saevarsdottir, S ...
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Catrina, Anca Ir ...
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Klinge, Björn
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Andersson, Ander ...
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Klareskog, Lars
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Lundberg, Karin
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Jansson, Leif
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Yucel-Lindberg, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Odontologi
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Malmö universitet
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Karolinska Institutet