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The interplay of el...
The interplay of electrode- and bio-materials in a redox-cycling-based clozapine sensor
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- Winkler, Thomas, Ph.D. (författare)
- Univ Maryland, Inst Syst Res, Dept Elect & Comp Engn, MEMS Sensors & Actuators Lab, College Pk, MD 20742 USA.;Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA
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- Dietrich, Robert (författare)
- Univ Maryland, Inst Syst Res, Dept Elect & Comp Engn, MEMS Sensors & Actuators Lab, College Pk, MD 20742 USA.;Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.
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- Kim, Eunkyoung (författare)
- Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA.
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- Ben-Yoav, Hadar (författare)
- Univ Maryland, Inst Syst Res, Dept Elect & Comp Engn, MEMS Sensors & Actuators Lab, College Pk, MD 20742 USA.;Ben Gurion Univ Negev, Dept Biomed Engn, IL-8410501 Beer Sheva, Israel.
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- Kelly, Deanna L. (författare)
- Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Baltimore, MD 21228 USA.
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- Payne, Gregory F. (författare)
- Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.;Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA.
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- Ghodssi, Reza (författare)
- Univ Maryland, Inst Syst Res, Dept Elect & Comp Engn, MEMS Sensors & Actuators Lab, College Pk, MD 20742 USA.;Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.
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Univ Maryland, Inst Syst Res, Dept Elect & Comp Engn, MEMS Sensors & Actuators Lab, College Pk, MD 20742 USA;Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA Univ Maryland, Inst Syst Res, Dept Elect & Comp Engn, MEMS Sensors & Actuators Lab, College Pk, MD 20742 USA.;Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. (creator_code:org_t)
- Elsevier, 2017
- 2017
- Engelska.
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Ingår i: Electrochemistry communications. - : Elsevier. - 1388-2481 .- 1873-1902. ; 79, s. 33-36
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We investigate gold, TiN, and platinum in combination with a chitosan catechol-based redox-cycling system (RCS) for electrochemical detection of the antipsychotic clozapine. We have previously demonstrated the RCS for detection of clozapine in serum, but challenges remain regarding low signal-to-noise ratios. This can be mitigated by selection of electrode materials with beneficial surface morphologies and/or compositions. We employ cyclic voltammetry to assess the redox current generated by clozapine, and differentiate solely surface area-based effects from clozapine-specific ones using a standard redox couple. We find that nano- and microstructured platinum greatly amplifies the clozapine signal compared to gold (up to 1490-fold for platinum black). However, the material performs poorly in the presence of chloride ions, and RCS modification provides no further amplification. The RCS combined with atomic-layer-deposited (ALD) TiN, on the other hand, increases the signal by 7.54 times, versus 2.86 times for RCS on gold, with a 9.2-fold lower variability, indicating that the homogenous and chemically inert properties of ALD-TiN may make it an ideal electrode material.
Ämnesord
- NATURVETENSKAP -- Kemi -- Annan kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)
Nyckelord
- Therapeutic drug monitoring
- Clozapine
- Redox cycling
- Titanium nitride
- Platinum black
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- art (ämneskategori)
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