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A Quantitative Stud...
A Quantitative Study of the Secondary Acoustic Radiation Force on Biological Cells during Acoustophoresis
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- Saeidi, Davood (författare)
- KTH,Tillämpad fysik,Albanova VinnExcellence Center for Protein Technology, ProNova,Isfahan Univ Technol, Dept Mech Engn, Esfahan 8415683111, Iran.
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- Saghafian, Mohsen (författare)
- Isfahan Univ Technol, Dept Mech Engn, Esfahan 8415683111, Iran.
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- Javanmard, Shaghayegh Haghjooy (författare)
- Isfahan Univ Med Sci, Appl Physiol Res Ctr, Cardiovasc Res Inst, Dept Physiol, Esfahan 81745, Iran.
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- Wiklund, Martin (författare)
- KTH,Biomedicinsk fysik och röntgenfysik,Albanova VinnExcellence Center for Protein Technology, ProNova
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(creator_code:org_t)
- 2020-01-30
- 2020
- Engelska.
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Ingår i: Micromachines. - : MDPI. - 2072-666X. ; 11:2
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- We investigate cell-particle secondary acoustic radiation forces in a plain ultrasonic standing wave field inside a microfluidic channel. The effect of secondary acoustic radiation forces on biological cells is measured in a location between a pressure node and a pressure anti-node and the result is compared with theory by considering both compressibility and density dependent effects. The secondary acoustic force between motile red blood cells (RBCs) and MCF-7 cells and fixed 20 mu m silica beads is investigated in a half-wavelength wide microchannel actuated at 2 MHz ultrasonic frequency. Our study shows that the secondary acoustic force between cells in acoustofluidic devices could play an important role for cell separation, sorting, and trapping purposes. Our results also demonstrate the possibility to isolate individual cells at trapping positions provided by silica beads immobilized and adhered to the microchannel bottom. We conclude that during certain experimental conditions, the secondary acoustic force acting on biological cells can dominate over the primary acoustic radiation force, which could open up for new microscale acoustofluidic methods.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering (hsv//eng)
Nyckelord
- acoustophoresis
- secondary acoustic radiation forces
- cell manipulation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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