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Intima-Media Thickn...
Intima-Media Thickness of Common Carotid and Brachial Arteries and Prothrombin Fragment 1+2 Are Associated with Left Ventricular Diastolic Dysfunction in Patients with Myocardial Infarction
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- Henareh, Loghman (författare)
- Karolinska Institutet
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Jedefors, Camilla (författare)
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- Jogestrand, Tomas (författare)
- Karolinska Institutet
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- Brodin, Lars Åke (författare)
- Karolinska Institutet,KTH,Medicinsk teknik
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- Agewall, Stefan (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2010-04-16
- 2010
- Engelska.
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Ingår i: Echocardiography. - : Wiley. - 0742-2822 .- 1540-8175. ; 27:6, s. 651-658
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aims: To investigate the association between intima-media thickness of brachial and common carotid arteries and factors of the coagulation- and fibrinolysis-system with left ventricular diastolic dysfunction in patients with a previous myocardial infarction. Patients and methods: One hundred and twenty three patients, men (76%) and women (24%) aged between 32and 81 years with a history of previous acute myocardial infarction were included. B-mode ultrasound of common carotid and brachial arteries and echocardiography with tissue Doppler imaging (TDI) were evaluated. Factors of the coagulation- and fibrinolysis-system were also measured. Results: In patients with previous myocardial infarction, late diastolic filling time was significantly and positively associated with log Prothrombin fragment 1 + 2 (P < 0.001) and with calculated intima-media area (cIMa) of the both common carotid and brachial arteries (P < 0.05). Mitral early-to-late flow velocity ratio (E/A) was significantly and negatively associated with log Prothrombin fragment 1 + 2 (P < 0.001), total cholesterol and cIMa of the both common carotid and brachial arteries (P < 0.05). Moreover both late diastolic filling time and mitral E/A correlated significantly with age and systolic blood pressure. In stepwise multiple regression analysis, log Prothrombin fragment 1 + 2 remained the only variable with independent significant correlation to late diastolic filling time and mitral E/A. Conclusions: In a population sample of patients with myocardial infarction, late diastolic filling time and mitral E/A were associated with cIMa of common carotid and brachial arteries, systolic blood pressure, and prothrombin fragment 1 + 2, suggesting a relationship between diastolic dysfunction, thrombin generation and atherosclerosis. (Echocardiography 2010;27:651-658).
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
Nyckelord
- tissue Doppler imaging
- Prothrombin fragment 1+2
- Medical engineering
- Medicinsk teknik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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