Staphylococcus aureus sub-typing and detection of MRSA on a microfluidic lab-on-foil device

• Emerging antibiotic multi-resistance, increased travel and trade, and environmental changes have contributed to the prevalence of infectious diseases and rapid changes in the efficiency of therapeutics. We report detection of multi-resistant Staphylococus aureus and S. aureus strain sub-types using a microfluidic detection module with integrated thin film heater and DNA microarray, which enables surface-bound melting curve analysis. Successful discrimination between clinical S. aureus strain sub-types and between methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) was demonstrated. The microfluidic detection module is constructed completely on a plastic foil using roll-to-roll compatible fabrication methods that yield a very low-cost system. Copyright 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Antibiotic resistance

Infectious diseases

Lab-on-foil

SNP

Antibiotics

Bacteria

Diseases

Microfluidics

Environmental change

Fabrication method

Infectious disease

Integrated thin film heater

Melting curve analysis

Microfluidic detection

Staphylococus aureus

Staphylococcus aureus

Publikations- och innehållstyp

ref (ämneskategori)

kon (ämneskategori)