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Sökning: onr:"swepub:oai:DiVA.org:kth-281143" > Spatial Transcripto...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006523naa a2200565 4500
001oai:DiVA.org:kth-281143
003SwePub
008201007s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2811432 URI
0247 a https://doi.org/10.1016/j.cell.2020.06.0382 DOI
040 a (SwePub)kth
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Chen, Wei-Tingu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut
2451 0a Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease
264 1b Elsevier BV,c 2020
338 a print2 rdacarrier
500 a QC 20201007
520 a Although complex inflammatory-like alterations are observed around the amyloid plaques of Alzheimer's disease (AD), little is known about the molecular changes and cellular interactions that characterize this response, We investigate here, in an AD mouse model, the transcriptional changes occurring in tissue domains in a 100-mu m diameter around amyloid plaques using spatial transcriptomics. We demonstrate early alterations in a gene co-expression network enriched for myelin and oligodendrocyte genes (OLIGs), whereas a multicellular gene co-expression network of plaque-induced genes (PIGs) involving the complement system, oxidative stress, lysosomes, and inflammation is prominent in the later phase of the disease. We confirm the majority of the observed alterations at the cellular level using in situ sequencing on mouse and human brain sections. Genome-wide spatial transcriptomics analysis provides an unprecedented approach to untangle the dysregulated cellular network in the vicinity of pathogenic hallmarks of AD and other brain diseases.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
7001 a Lu, Ashleyu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut
7001 a Craessaerts, Katleenu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut
7001 a Pavie, Benjaminu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;VIB Bio Imaging Core, B-9052 Ghent, Belgium.;VIB Bio Imaging Core, B-3000 Leuven, Belgium.4 aut
7001 a Frigerio, Carlo Salau VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;UCL, UK Dementia Res Inst, London WC1E 6BT, England.4 aut
7001 a Corthout, Nikkyu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;VIB Bio Imaging Core, B-9052 Ghent, Belgium.;VIB Bio Imaging Core, B-3000 Leuven, Belgium.4 aut
7001 a Qian, Xiaoyanu Cartana AB, Nobels Vag 16, S-17165 Solna, Sweden.4 aut
7001 a Lalakova, Janau Cartana AB, Nobels Vag 16, S-17165 Solna, Sweden.4 aut
7001 a Kuhnemund, Malteu Cartana AB, Nobels Vag 16, S-17165 Solna, Sweden.4 aut
7001 a Voytyuk, Irynau VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut
7001 a Wolfs, Leenu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut
7001 a Mancuso, Renzou VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut
7001 a Salta, Evgeniau VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut
7001 a Balusu, Sriramu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut
7001 a Snellinx, Anu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut
7001 a Munck, Sebastianu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;VIB Bio Imaging Core, B-9052 Ghent, Belgium.;VIB Bio Imaging Core, B-3000 Leuven, Belgium.4 aut
7001 a Jurek, Aleksandrau KTH,Genteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1qtfp9v
7001 a Fernandez Navarro, Joseu KTH,Genteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u11gbovc
7001 a Saido, Takaomi C.u RIKEN Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan.4 aut
7001 a Huitinga, Ingeu Royal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, Dept Neuroimmunol, NL-1105 BA Amsterdam, Netherlands.;Univ Amsterdam, Swammerdam Inst Life Sci, NL-1098 XH Amsterdam, Netherlands.4 aut
7001 a Lundeberg, Joakimu KTH,Science for Life Laboratory, SciLifeLab,Genteknologi4 aut0 (Swepub:kth)u1qkn9kw
7001 a Fiers, Marku VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;UCL, UK Dementia Res Inst, London WC1E 6BT, England.4 aut
7001 a De Strooper, Bartu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;UCL, UK Dementia Res Inst, London WC1E 6BT, England.4 aut
7102 a VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.b VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;VIB Bio Imaging Core, B-9052 Ghent, Belgium.;VIB Bio Imaging Core, B-3000 Leuven, Belgium.4 org
7730 t Celld : Elsevier BVg 182:4, s. 976-+q 182:4<976-+x 0092-8674x 1097-4172
8564 u http://www.cell.com/article/S0092867420308151/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-281143
8564 8u https://doi.org/10.1016/j.cell.2020.06.038

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