Sökning: onr:"swepub:oai:DiVA.org:kth-283157" > Molecular packing s...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04772naa a2200457 4500 | |
001 | oai:DiVA.org:kth-283157 | |
003 | SwePub | |
008 | 201006s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2831572 URI |
024 | 7 | a https://doi.org/10.1039/d0sm00916d2 DOI |
040 | a (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Jansen, Karin A.u AMOLF, Biol Soft Matter Grp, Utrecht, Netherlands.;UMC Utrecht, Dept Pathol, NL-3508 GA Utrecht, Netherlands.4 aut |
245 | 1 0 | a Molecular packing structure of fibrin fibers resolved by X-ray scattering and molecular modeling |
264 | c 2020 | |
264 | 1 | b Royal Society of Chemistry (RSC),c 2020 |
338 | a print2 rdacarrier | |
500 | a QC 20201006 | |
520 | a Fibrin is the major extracellular component of blood clots and a proteinaceous hydrogel used as a versatile biomaterial. Fibrin forms branched networks built of laterally associated double-stranded protofibrils. This multiscale hierarchical structure is crucial for the extraordinary mechanical resilience of blood clots, yet the structural basis of clot mechanical properties remains largely unclear due, in part, to the unresolved molecular packing of fibrin fibers. Here the packing structure of fibrin fibers is quantitatively assessed by combining Small Angle X-ray Scattering (SAXS) measurements of fibrin reconstituted under a wide range of conditions with computational molecular modeling of fibrin protofibrils. The number, positions, and intensities of the Bragg peaks observed in the SAXS experiments were reproduced computationally based on the all-atom molecular structure of reconstructed fibrin protofibrils. Specifically, the model correctly predicts the intensities of the reflections of the 22.5 nm axial repeat, corresponding to the half-staggered longitudinal arrangement of fibrin molecules. In addition, the SAXS measurements showed that protofibrils within fibrin fibers have a partially ordered lateral arrangement with a characteristic transverse repeat distance of 13 nm, irrespective of the fiber thickness. These findings provide fundamental insights into the molecular structure of fibrin clots that underlies their biological and physical properties. | |
650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
700 | 1 | a Zhmurov, Artemu KTH,Parallelldatorcentrum, PDC,Sechenov Univ, Moscow 119991, Russia.4 aut0 (Swepub:kth)u17tvbr9 |
700 | 1 | a Vos, Bart E.u AMOLF, Biol Soft Matter Grp, Utrecht, Netherlands.;Univ Munster, Ctr Mol Biol Inflammat, Inst Cell Biol, Munster, Germany.4 aut |
700 | 1 | a Portale, Giuseppeu Univ Groningen, Zernike Inst Adv Mat, Macromol Chem & New Polymer Mat, Nijenborgh 4, NL-9747 AG Groningen, Netherlands.4 aut |
700 | 1 | a Hermida-Merino, Danielu ESRF, DUBBLE CRG, Netherlands Org Sci Res NWO, 71 Ave Martyrs, F-38000 Grenoble, France.4 aut |
700 | 1 | a Litvinov, Rustem, Iu Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA.;Kazan Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia.4 aut |
700 | 1 | a Tutwiler, Valerieu Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA.4 aut |
700 | 1 | a Kurniawan, Nicholas A.u AMOLF, Biol Soft Matter Grp, Utrecht, Netherlands.;Eindhoven Univ Technol, Dept Biomed Engn, Eindhoven, Netherlands.;Eindhoven Univ Technol, Inst Complex Mol Syst, Eindhoven, Netherlands.4 aut |
700 | 1 | a Bras, Wimu ESRF, DUBBLE CRG, Netherlands Org Sci Res NWO, 71 Ave Martyrs, F-38000 Grenoble, France.;Oak Ridge Natl Lab, Chem Sci Div, One Bethel Valley Rd, Oak Ridge, TN 37831 USA.4 aut |
700 | 1 | a Weisel, John W.u Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA.4 aut |
700 | 1 | a Barsegov, Valeriu Univ Massachusetts, Dept Chem, 1 Univ Ave, Lowell, MA 01854 USA.4 aut |
700 | 1 | a Koenderink, Gijsje H.u AMOLF, Biol Soft Matter Grp, Utrecht, Netherlands.;Delft Univ Technol, Kavli Inst Nanosci Delft, Dept Bionanosci, Maasweg 9, NL-2629 HZ Delft, Netherlands.4 aut |
710 | 2 | a AMOLF, Biol Soft Matter Grp, Utrecht, Netherlands.;UMC Utrecht, Dept Pathol, NL-3508 GA Utrecht, Netherlands.b Parallelldatorcentrum, PDC4 org |
773 | 0 | t Soft Matterd : Royal Society of Chemistry (RSC)g 16:35, s. 8272-8283q 16:35<8272-8283x 1744-683Xx 1744-6848 |
856 | 4 | u https://doi.org/10.1039/d0sm00916dy Fulltext |
856 | 4 | u https://pubs.rsc.org/en/content/articlepdf/2020/sm/d0sm00916d |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-283157 |
856 | 4 8 | u https://doi.org/10.1039/d0sm00916d |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy