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Hypoxia gradually a...
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Keramidas, Michail E.,Assistant ProfessorKTH,Omgivningsfysiologi
(författare)
Hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole-body cold stress in humans
- Artikel/kapitelEngelska2020
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2020
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LIBRIS-ID:oai:DiVA.org:kth-284590
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-284590URI
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https://doi.org/10.1113/EP089070DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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QC 20201130
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We examined whether hypoxia would modulate thermoeffector responses during repeated cold stress encountered in a single day. Eleven men completed two ∼10 h sessions, while breathing, in normobaria, either normoxia or hypoxia (PO2 : 12 kPa). During each session, subjects underwent sequentially three 120 min immersions to the chest in 20◦C water (CWI), interspersed by 120 min rewarming. In normoxia, the final drop in rectal temperature (Trec) was greater in the third (∼1.2◦C) than in the first and second (∼0.9◦C) CWIs (P < 0.05). The first hypoxic CWI augmented the Trec fall (∼1.2◦C; P = 0.002), but the drop in Trec did not vary between the three hypoxic CWIs (P = 0.99). In normoxia, the metabolic heat production (Ṁ ) was greater during the first half of the third CWI than during the corresponding part of the first CWI (P = 0.02); yet the difference was blunted during the second half of the CWIs (P = 0.89). In hypoxia, by contrast, the increase in Ṁ was augmented by ∼25% throughout the third CWI (P < 0.01). Regardless of the breathing condition, the cold-induced elevation in mean arterial pressure was blunted in the second and third CWI (P < 0.05). Hypoxia aggravated the sensation of coldness (P = 0.05) and thermal discomfort (P = 0.04) during the second half of the third CWI. The present findings therefore demonstrate that prolonged hypoxia mediates, in a gradual manner, metabolic and thermoperceptual sensitization to repeated cold stress.
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Kölegård, RogerKTH,Omgivningsfysiologi(Swepub:kth)u1nydatc
(författare)
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Eiken, OlaKTH,Omgivningsfysiologi(Swepub:kth)u1fcwvxl
(författare)
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KTHOmgivningsfysiologi
(creator_code:org_t)
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Ingår i:Experimental Physiology105, s. 2123-21400958-06701469-445X
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