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Facile Nanoimprinti...
Facile Nanoimprinting of Robust High-Aspect-Ratio Nanostructures for Human Cell Biomechanics
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- Shafagh, Reza Zandi (författare)
- Karolinska Institutet,KTH,Mikro- och nanosystemteknik
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- Shen, Joanne X. (författare)
- Karolinska Institutet
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- Youhanna, Sonia (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
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- Guo, Weijin (författare)
- KTH,Mikro- och nanosystemteknik
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- Lauschke, Volker M. (författare)
- Karolinska Institutet
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- van der Wijngaart, Wouter (författare)
- KTH,Mikro- och nanosystemteknik
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- Haraldsson, Klas Tommy (författare)
- KTH,Mikro- och nanosystemteknik
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(creator_code:org_t)
- 2020-11-10
- 2020
- Engelska.
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Ingår i: ACS Applied Bio Materials. - : American Chemical Society (ACS). - 2576-6422. ; 3:12, s. 8757-8767
- Relaterad länk:
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https://doi.org/10.1...
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https://pubs.acs.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- High-aspect-ratio and hierarchically nanostructured surfaces are common in nature. Synthetic variants are of interest for their specific chemical, mechanic, electric, photonic, or biologic properties but are cumbersome in fabrication or suffer from structural collapse. Here, we replicated and directly biofunctionalized robust, large-area, and high-aspect-ratio nanostructures by nanoimprint lithography of an off-stoichiometric thiol–ene-epoxy polymer. We structured—in a single-step process—dense arrays of pillars with a diameter as low as 100 nm and an aspect ratio of 7.2; holes with a diameter of 70 nm and an aspect ratio of >20; and complex hierarchically layered structures, all with minimal collapse and defectivity. We show that the nanopillar arrays alter mechanosensing of human hepatic cells and provide precise spatial control of cell attachment. We speculate that our results can enable the widespread use of high-aspect-ratio nanotopograhy applications in mechanics, optics, and biomedicine.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
Nyckelord
- nanoimprint lithography
- high aspect ratio
- thiol−ene-epoxy
- cells
- biomechanics
- cell attachment
- protein patterning
- nanoscale
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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