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Longitudinal In-Viv...
Longitudinal In-Vivo X-Ray Fluorescence Computed Tomography With Molybdenum Nanoparticles
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- Shaker, Kian (författare)
- KTH,Biomedicinsk fysik och röntgenfysik,Albanova VinnExcellence Center for Protein Technology, ProNova
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- Vogt, Carmen (författare)
- KTH,Biomedicinsk fysik och röntgenfysik,Albanova VinnExcellence Center for Protein Technology, ProNova
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- Katsu-Jimenez, Yurika (författare)
- Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, S-17177 Solna, Sweden.
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- Kuiper, Raoul V. (författare)
- Karolinska Institutet
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- Andersson, Kenth (författare)
- KTH,Albanova VinnExcellence Center for Protein Technology, ProNova,Tillämpad fysik
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- Li, Yuyang (författare)
- KTH,Albanova VinnExcellence Center for Protein Technology, ProNova,Biomedicinsk fysik och röntgenfysik
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- Larsson, Jakob C. (författare)
- KTH,Albanova VinnExcellence Center for Protein Technology, ProNova,Biomedicinsk fysik och röntgenfysik
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- Rodriguez-Garcia, Aida (författare)
- Karolinska Institutet
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- Toprak, Muhammet, 1973- (författare)
- KTH,Albanova VinnExcellence Center for Protein Technology, ProNova,Tillämpad fysik
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- Arsenian-Henriksson, Marie (författare)
- Karolinska Institutet
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- Hertz, Hans (författare)
- KTH,Albanova VinnExcellence Center for Protein Technology, ProNova,Tillämpad fysik
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(creator_code:org_t)
- Institute of Electrical and Electronics Engineers (IEEE), 2020
- 2020
- Engelska.
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Ingår i: IEEE Transactions on Medical Imaging. - : Institute of Electrical and Electronics Engineers (IEEE). - 0278-0062 .- 1558-254X. ; 39:12, s. 3910-3919
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- X-ray fluorescence computed tomography (XFCT) with nanoparticles (NPs) as contrast agents shows potential for molecular biomedical imaging with higher spatial resolution than present methods. To date the technique has been demonstrated on phantoms and mice, however, parameters such as radiation dose, exposure times and sensitivity have not yet allowed for high-spatial-resolution in vivo longitudinal imaging, i.e., imaging of the same animal at different time points. Here we show in vivo XFCT with spatial resolution in the 200-400 mu m range in a proof-of-principle longitudinal study where mice are imaged five times each during an eight-week period following tail-vein injection of NPs. We rely on a 24 keV x-ray pencil-beam-based excitation of in-house-synthesized molybdenum oxide NPs (MoO2) to provide the high signal-to-background x-ray fluorescence detection necessary for XFCT imaging with low radiation dose and short exposure times. We quantify the uptake and clearance of NPs in vivo through imaging, and monitor animal well-being over the course of the study with support from histology and DNA stability analysis to assess the impact of x-ray exposure and NPs on animal welfare. We conclude that the presented imaging arrangement has potential for in vivo longitudinal studies, putting emphasis on designing biocompatible NPs as the future focus for active-targeting preclinical XFCT.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Biomedical imaging
- computed tomography (CT)
- in vivo
- molecular imaging
- nanoparticles
- preclinical imaging
- X-ray fluorescence computed tomography (XFCT)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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