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Sökning: onr:"swepub:oai:DiVA.org:kth-288671" > Clear mortality gap...

Clear mortality gap caused by graft macrosteatosis in Chinese patients after cadaveric liver transplantation

Liu, Zhengtao (författare)
Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med, Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Peoples R China.
Wang, Wenchao (författare)
Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Peoples R China.
Zhuang, Li (författare)
Shuren Univ, Shulan Int Med Coll, Shulan Hangzhou Hosp, Hangzhou, Peoples R China.
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Liu, Jingfeng (författare)
Shuren Univ, Shulan Int Med Coll, Shulan Hangzhou Hosp, Hangzhou, Peoples R China.
Que, Shuping (författare)
KTH,Science for Life Laboratory, SciLifeLab,Dingxiang Clin, Hangzhou, Peoples R China.
Zhu, Dan (författare)
Shuren Univ, Shulan Int Med Coll, Shulan Hangzhou Hosp, Hangzhou, Peoples R China.
Dong, Linfang (författare)
Shuren Univ, Shulan Int Med Coll, Shulan Hangzhou Hosp, Hangzhou, Peoples R China.
Yu, Jian (författare)
Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China.
Zhou, Lin (författare)
Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med, Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Peoples R China.
Zheng, Shusen (författare)
Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med, Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Peoples R China.;Shuren Univ, Shulan Int Med Coll, Shulan Hangzhou Hosp, Hangzhou, Peoples R China.
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Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med, Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Peoples R China. Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Peoples R China. (creator_code:org_t)
2020-12
2020
Engelska.
Ingår i: Hepatobiliary surgery and nutrition. - : AME Publishing Company. - 2304-3881 .- 2304-389X. ; 9:6, s. 739-758
Relaterad länk:
https://hbsn.amegrou...
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https://urn.kb.se/re...
https://doi.org/10.2...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Liver transplantation (LT) is one of the most effective surgical treatment for patients with end-stage liver disease. Steatosis is a contributor for inferior graft quality. But its impact and safety on transplantation was less assessed in Chinese patients. Methods: Graft steatosis and related information involved in recipients, donors and surgical procedures were retrospectively collected from 239 patients. Results: Donor macrosteatosis (MaS) caused about 2.14 and 2.80 folds of increment on patient and graft mortality. Dose-response analysis revealed prominent risk of grafts on overall patient/organ mortality when MaS content exceeded 10% (P<0.05). Noteworthy, deaths were only observed in MaS group when concurrent with extremely higher post-transplant alanine aminotransferase (ALT, 64%). However, microsteatosis (MiS) grafts didn't affect outcomes after LT. In a cohort of Chinese patients, MaS had comprehensive effects on post-transplant outcomes with relatively lower safety threshold at 10%. Mortality gap caused by MaS grafts was observed in patients with severer ischemia reperfusion injury. Conclusions: Our study revealled the graft MaS affected the post-transplant outcomes in lower risk cutoff in Chinese patients. Further study is worthy to validate these results and investigate inner mechanism under the phenomenon.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Steatosis
prognosis
liver transplantation (LT)
dose-response analysis

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Av författaren/redakt...
Liu, Zhengtao
Wang, Wenchao
Zhuang, Li
Liu, Jingfeng
Que, Shuping
Zhu, Dan
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Dong, Linfang
Yu, Jian
Zhou, Lin
Zheng, Shusen
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