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A microfluidic opti...
A microfluidic optical platform for real-time monitoring of pH and oxygen in microfluidic bioreactors and organ-on-chip devices
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Shaegh, S. A. M. (författare)
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De Ferrari, Fabio (författare)
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Zhang, Y. S. (författare)
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visa fler...
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Nabavinia, M. (författare)
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Mohammad, N. B. (författare)
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Ryan, J. (författare)
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Pourmand, A. (författare)
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Laukaitis, E. (författare)
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Sadeghian, R. B. (författare)
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Nadhman, A. (författare)
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Shin, S. R. (författare)
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Nezhad, A. S. (författare)
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Khademhosseini, A. (författare)
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Dokmeci, M. R. (författare)
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visa färre...
- American Institute of Physics (AIP), 2016
- 2016
- Engelska.
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Ingår i: Biomicrofluidics. - : American Institute of Physics (AIP). - 1932-1058. ; 10:4
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- There is a growing interest to develop microfluidic bioreactors and organ-on-chipplatforms with integrated sensors to monitor their physicochemical properties and tomaintain a well-controlled microenvironment for cultured organoids. Conventionalsensing devices cannot be easily integrated with microfluidic organ-on-chip systemswith low-volume bioreactors for continual monitoring. This paper reports on thedevelopment of a multi-analyte optical sensing module for dynamic measurementsof pH and dissolved oxygen levels in the culture medium. The sensing system wasconstructed using low-cost electro-optics including light-emitting diodes and siliconphotodiodes. The sensing module includes an optically transparent window formeasuring light intensity, and the module could be connected directly to a perfusionbioreactor without any specific modifications to the microfluidic device design. Acompact, user-friendly, and low-cost electronic interface was developed to controlthe optical transducer and signal acquisition from photodiodes. The platformenabled convenient integration of the optical sensing module with a microfluidicbioreactor. Human dermal fibroblasts were cultivated in the bioreactor, and thevalues of pH and dissolved oxygen levels in the flowing culture medium were measuredcontinuously for up to 3 days. Our integrated microfluidic system providesa new analytical platform with ease of fabrication and operation, which can beadapted for applications in various microfluidic cell culture and organ-on-chipdevices.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Shaegh, S. A. M.
-
De Ferrari, Fabi ...
-
Zhang, Y. S.
-
Nabavinia, M.
-
Mohammad, N. B.
-
Ryan, J.
-
visa fler...
-
Pourmand, A.
-
Laukaitis, E.
-
Sadeghian, R. B.
-
Nadhman, A.
-
Shin, S. R.
-
Nezhad, A. S.
-
Khademhosseini, ...
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Dokmeci, M. R.
-
visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
- Artiklar i publikationen
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Biomicrofluidics
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