Sökning: onr:"swepub:oai:DiVA.org:kth-291784" >
The Use of a Non-Co...
The Use of a Non-Conventional Long-Lived Gallium Radioisotope Ga-66 Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR:2377 Affibody Molecule
-
- Oroujeni, Maryam, PhD, 1982- (författare)
- Uppsala universitet,Medicinsk strålningsvetenskap,Vladimir Tolmachev
-
- Xu, Tianqi (författare)
- Uppsala universitet,Medicinsk strålningsvetenskap
-
- Gagnon, Katherine (författare)
- Uppsala universitet,Theranostics,GE Healthcare, GEMS PET Systems, 75015 Uppsala, Sweden
-
visa fler...
-
- Rinne, Sara S. (författare)
- Uppsala universitet,Theranostics
-
- Weis, Jan, 1956- (författare)
- Uppsala Univ Hosp, Dept Med Phys, S-75185 Uppsala, Sweden.,Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden
-
- Garousi, Javad (författare)
- Uppsala universitet,Medicinsk strålningsvetenskap
-
- Andersson, Ken G. (författare)
- KTH,Proteinvetenskap,Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden
-
- Löfblom, John (författare)
- KTH,Proteinvetenskap,Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden
-
- Orlova, Anna (författare)
- Uppsala universitet,Theranostics,Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia
-
- Tolmachev, Vladimir (författare)
- Uppsala universitet,Medicinsk strålningsvetenskap,Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia
-
visa färre...
-
(creator_code:org_t)
- 2021-02-23
- 2021
- Engelska.
-
Ingår i: Pharmaceutics. - : MDPI AG. - 1999-4923. ; 13:2
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://www.mdpi.com...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Epidermal growth factor receptor (EGFR) is overexpressed in many malignancies. EGFR-targeted therapy extends survival of patients with disseminated cancers. Radionuclide molecular imaging of EGFR expression would make EGFR-directed treatment more personalized and therefore more efficient. A previous study demonstrated that affibody molecule [Ga-68]Ga-DFO-ZEGFR:2377 permits specific positron-emission tomography (PET) imaging of EGFR expression in xenografts at 3 h after injection. We anticipated that imaging at 24 h after injection would provide higher contrast, but this is prevented by the short half-life of Ga-68 (67.6 min). Here, we therefore tested the hypothesis that the use of the non-conventional long-lived positron emitter Ga-66 (T-1/2 = 9.49 h, beta(+) = 56.5%) would permit imaging with higher contrast. Ga-66 was produced by the Zn-66(p,n)Ga-66 nuclear reaction and DFO-ZEGFR:2377 was efficiently labelled with Ga-66 with preserved binding specificity in vitro and in vivo. At 24 h after injection, [Ga-66]Ga-DFO-ZEGFR:2377 provided 3.9-fold higher tumor-to-blood ratio and 2.3-fold higher tumor-to-liver ratio than [Ga-68]Ga-DFO-ZEGFR:2377 at 3 h after injection. At the same time point, [Ga-66]Ga-DFO-ZEGFR:2377 provided 1.8-fold higher tumor-to-blood ratio, 3-fold higher tumor-to-liver ratio, 1.9-fold higher tumor-to-muscle ratio and 2.3-fold higher tumor-to-bone ratio than [Zr-89]Zr-DFO-ZEGFR:2377. Biodistribution data were confirmed by whole body PET combined with magnetic resonance imaging (PET/MRI). The use of the positron emitter Ga-66 for labelling of DFO-ZEGFR:2377 permits PET imaging of EGFR expression at 24 h after injection and improves imaging contrast.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- epidermal growth factor receptor
- affibody molecule
- PET imaging
- gallium-66
- ZEGFR
- 2377
- A431 xenograft
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Oroujeni, Maryam ...
-
Xu, Tianqi
-
Gagnon, Katherin ...
-
Rinne, Sara S.
-
Weis, Jan, 1956-
-
Garousi, Javad
-
visa fler...
-
Andersson, Ken G ...
-
Löfblom, John
-
Orlova, Anna
-
Tolmachev, Vladi ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Radiologi och bi ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Pharmaceutics
- Av lärosätet
-
Kungliga Tekniska Högskolan
-
Uppsala universitet