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Centrifugal microfl...
Centrifugal microfluidic platform comprising an array of bead microcolumns for the multiplexed colorimetric quantification of inflammatory biomarkers at the point-of-care
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- Akhtar, Ahmad Saleem (författare)
- KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab
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- Pinto, Ines Fernandes (författare)
- KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab
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- Soares, Ruben R. G. (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Nanobioteknologi
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visa fler...
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- Russom, Aman, Prof. 1976- (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Nanobioteknologi
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visa färre...
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(creator_code:org_t)
- Chemical and Biological Microsystems Society, 2019
- 2019
- Engelska.
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Ingår i: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. - : Chemical and Biological Microsystems Society. ; , s. 1230-1231
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The detection of panels of inflammatory biomarkers such as cytokines has potential for the rapid and specific diagnostic of several devastating diseases such as primary cancers and/or metastatic tumors, as opposed to less serious conditions. For point-of-care clinical applications, the detection of these biomarkers requires a combination of pg/mL sensitivities and multiplexing capabilities, coupled with fit-for-purpose signal transduction strategies. Here, we report the development of a versatile centrifugal microfluidic platform combined with nanoporous microbeads for immunoaffinity-based profiling of cytokines. The device allows sample and analyte multiplexing and detection limits below 1 ng/mL were achieved within 30 minutes, using colorimetric detection.
Ämnesord
- NATURVETENSKAP -- Kemi -- Annan kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)
Nyckelord
- Centrifugal microfluidics
- Colorimetry
- Cytokines
- Multiplexing
- Point-of-Care
- Antigen-antibody reactions
- Biomarkers
- Centrifugation
- Diagnosis
- Signal transduction
- Centrifugal microfluidic platform
- Clinical application
- Colorimetric detection
- Detection limits
- Fit for purpose
- Immunoaffinity
- Metastatic tumors
- Point of care
- Microfluidics
Publikations- och innehållstyp
- ref (ämneskategori)
- kon (ämneskategori)