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Stress-induced tran...
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Vihervaara, AnniinaKTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Abo Akad Univ, Fac Sci & Engn, Cell Biol, Turku 20520, Finland.;Univ Turku, Turku Biosci Ctr, Turku 20520, Finland.;Abo Akad Univ, Turku 20520, Finland.;Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA.
(författare)
Stress-induced transcriptional memory accelerates promoter-proximal pause release and decelerates termination over mitotic divisions
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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Elsevier BV,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:kth-296145
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-296145URI
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https://doi.org/10.1016/j.molcel.2021.03.007DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20210601
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Heat shock instantly reprograms transcription. Whether gene and enhancer transcription fully recover from stress and whether stress establishes a memory by provoking transcription regulation that persists through mitosis remained unknown. Here, we measured nascent transcription and chromatin accessibility in unconditioned cells and in the daughters of stress-exposed cells. Tracking transcription genome-wide at nucleotide-resolution revealed that cells precisely restored RNA polymerase II (Pol II) distribution at gene bodies and enhancers upon recovery from stress. However, a single heat exposure in embryonic fibroblasts primed a faster gene induction in their daughter cells by increasing promoter-proximal Pol II pausing and by accelerating the pause release. In K562 erythroleukemia cells, repeated stress refined basal and heat-induced transcription over mitotic division and decelerated termination-coupled pre-mRNA processing. The slower termination retained transcripts on the chromatin and reduced recycling of Pol II. These results demonstrate that heat-induced transcriptional memory acts through promoter-proximal pause release and pre-mRNA processing at transcription termination.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mahat, Dig BijayCornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA.;MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
(författare)
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Himanen, Samu, VAbo Akad Univ, Fac Sci & Engn, Cell Biol, Turku 20520, Finland.;Univ Turku, Turku Biosci Ctr, Turku 20520, Finland.;Abo Akad Univ, Turku 20520, Finland.
(författare)
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Blom, Malin A. H.Abo Akad Univ, Fac Sci & Engn, Cell Biol, Turku 20520, Finland.;Univ Turku, Turku Biosci Ctr, Turku 20520, Finland.;Abo Akad Univ, Turku 20520, Finland.
(författare)
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Lis, John T.Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA.
(författare)
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Sistonen, LeaAbo Akad Univ, Fac Sci & Engn, Cell Biol, Turku 20520, Finland.;Univ Turku, Turku Biosci Ctr, Turku 20520, Finland.;Abo Akad Univ, Turku 20520, Finland.
(författare)
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KTHGenteknologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecular Cell: Elsevier BV81:8, s. 1715-+1097-27651097-4164
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