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Inflammation and Ap...
Inflammation and Apolipoproteins Are Potential Biomarkers for Stratification of Cutaneous Melanoma Patients for Immunotherapy and Targeted Therapy
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- Karlsson, Max J. (författare)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Svedman, Fernanda Costa (författare)
- Karolinska Institutet
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- Abdellah, Tebani (författare)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Kotol, David (författare)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Hoiom, Veronica (författare)
- Karolinska Institutet
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- Fagerberg, Linn (författare)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Edfors, Fredrik (författare)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Uhlén, Mathias (författare)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Neurosci, Stockholm, Sweden.;Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, Lyngby, Denmark.
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- Brage, Suzanne Egyhazi (författare)
- Karolinska Institutet
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- Maddalo, Gianluca (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- American Association for Cancer Research (AACR), 2021
- 2021
- Engelska.
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Ingår i: Cancer Research. - : American Association for Cancer Research (AACR). - 0008-5472 .- 1538-7445. ; 81:9, s. 2545-2555
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Malignant cutaneous melanoma is one of the most common cancers in young adults. During the last decade, targeted and immunotherapies have significantly increased the overall survival of patients with malignant cutaneous melanoma. Nevertheless, disease progression is common, and a lack of predictive biomarkers of patient response to therapy hinders individualized treatment strategies. To address this issue, we performed a longitudinal study using an unbiased proteomics approach to identify and quantify proteins in plasma both before and during treatment from 109 patients treated with either targeted or immunotherapy. Linear modeling and machine learning approaches identified 43 potential prognostic and predictive biomarkers. A reverse correlation between apolipoproteins and proteins related to inflammation was observed. In the immunotherapy group, patients with low pretreatment expression of apolipoproteins and high expression of inflammation markers had shorter progression-free survival. Similarly, increased expression of LDHB during treatment elicited a significant impact on response to immunotherapy. Overall, we identified potential common and treatment-specific biomarkers in malignant cutaneous melanoma, paving the way for clinical use of these biomarkers following validation on a larger cohort. Significance: This study identifies a potential biomarker panel that could improve the selection of therapy for patients with cutaneous melanoma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Karlsson, Max J.
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Svedman, Fernand ...
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Abdellah, Tebani
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Kotol, David
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Hoiom, Veronica
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Fagerberg, Linn
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visa fler...
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Edfors, Fredrik
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Uhlén, Mathias
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Brage, Suzanne E ...
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Maddalo, Gianluc ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Cancer Research
- Av lärosätet
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Kungliga Tekniska Högskolan
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Karolinska Institutet