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Dual-drug delivery ...
Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers
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- Hussein, Mohamed Ahmed Mohamady (författare)
- Univ Hosp RWTH Aachen, Dermatol Clin, D-52074 Aachen, Germany.;Natl Res Ctr, Div Med Res, Dept Pharmacol, Cairo 12622, Egypt.
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- Guler, Ece (författare)
- Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey.;Marmara Univ, Dept Pharmacol, Fac Pharm, TR-34716 Istanbul, Turkey.
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- Rayaman, Erkan (författare)
- Marmara Univ, Dept Pharmaceut Microbiol, Istanbul, Turkey.
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- Cam, Muhammet Emin (författare)
- Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey.;Marmara Univ, Dept Pharmacol, Fac Pharm, TR-34716 Istanbul, Turkey.;UCL, Dept Mech Engn, Torrington Pl, London W E 7JE, England.
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- Sahin, Ali (författare)
- Marmara Univ, Sch Med, Dept Biochem, Genet & Metab Dis Res & Invest Ctr, TR-34722 Istanbul, Turkey.
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- Grinholc, Mariusz (författare)
- Univ Gdansk, Intercollegiate Fac Biotechnol, Dept Biotechnol, Lab Mol Diagnost, Gdansk, Poland.
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- Mansuroglu, Demet Sezgin (författare)
- Istanbul Arel Univ, Polymer Technol & Composite Applicat & Res Ctr Ar, TR-34537 Istanbul, Turkey.
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- Sahin, Yesim Muge (författare)
- Istanbul Arel Univ, Polymer Technol & Composite Applicat & Res Ctr Ar, TR-34537 Istanbul, Turkey.
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- Gunduz, Oguzhan (författare)
- Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey.
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- Muhammed, Mamoun (författare)
- KTH
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- El-Sherbiny, Ibrahim M. (författare)
- Zewail City Sci & Technol, Ctr Mat Sci CMS, Nanomed Lab, Giza 12578, Egypt.
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- Megahed, Mosaad (författare)
- Univ Hosp RWTH Aachen, Dermatol Clin, D-52074 Aachen, Germany.
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Univ Hosp RWTH Aachen, Dermatol Clin, D-52074 Aachen, Germany;Natl Res Ctr, Div Med Res, Dept Pharmacol, Cairo 12622, Egypt. Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey.;Marmara Univ, Dept Pharmacol, Fac Pharm, TR-34716 Istanbul, Turkey. (creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: Carbohydrate Polymers. - : Elsevier BV. - 0144-8617 .- 1879-1344. ; 270
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity. For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer. The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC. The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs. There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs. The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Biomaterial (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bio Materials (hsv//eng)
Nyckelord
- Silver nanoparticles
- Chitosan
- Phenytoin
- Dual-drug delivery
- Core-shell nanofibers
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Till lärosätets databas
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Hussein, Mohamed ...
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Guler, Ece
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Rayaman, Erkan
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Cam, Muhammet Em ...
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Sahin, Ali
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Grinholc, Marius ...
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Mansuroglu, Deme ...
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Sahin, Yesim Mug ...
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Gunduz, Oguzhan
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Muhammed, Mamoun
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El-Sherbiny, Ibr ...
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Megahed, Mosaad
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Industriell biot ...
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och Biomaterial
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Carbohydrate Pol ...
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